Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons (Q71786314)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8922409%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

title

Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8922409%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

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E Paradis

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6579094&resulttype=core&format=json

15 May 2020

H Douillard

2

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15 May 2020

M Koutroumanis

3

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15 May 2020

C Goodyer

4

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15 May 2020

A LeBlanc

5

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15 May 2020

publication date

1 December 1996

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8922409%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

published in

Journal of Neuroscience

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15 May 2020

volume

16

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15 May 2020

issue

23

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15 May 2020

page(s)

7533-7539

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Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

15 May 2020

cites work

1 reference

12 December 2020

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

1 reference

12 December 2020

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

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12 December 2020

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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12 December 2020

The protooncogene bcl-2 inhibits apoptosis in PC12 cells

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12 December 2020

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

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12 December 2020

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

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12 December 2020

Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene

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12 December 2020

Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death.

1 reference

12 December 2020

Bcl-2 affects survival but not neuronal differentiation of PC12 cells

1 reference

12 December 2020

Oxidative stress, glutamate, and neurodegenerative disorders

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12 December 2020

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

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12 December 2020

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

12 December 2020

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

12 December 2020

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.

1 reference

12 December 2020

Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death

1 reference

12 December 2020

Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.

1 reference

12 December 2020

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1 reference

12 December 2020

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

1 reference

12 December 2020

Concentrations of amyloid-beta protein in cerebrospinal fluid increase with age in patients free from neurodegenerative disease

1 reference

12 December 2020

Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis

1 reference

12 December 2020

Early Alzheimer disease-like histopathology increases in frequency with age in mice transgenic for beta-APP751.

1 reference

12 December 2020

beta-Amyloid-mediated vasoactivity and vascular endothelial damage.

1 reference

12 December 2020

1 reference

12 December 2020

Programmed cell death and Bcl-2 protection in very low oxygen.

1 reference

12 December 2020

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

1 reference

12 December 2020

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

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12 December 2020

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

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12 December 2020

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

1 reference

12 December 2020

Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome

1 reference

12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

12 December 2020

Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype

1 reference

12 December 2020

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

12 December 2020

Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35.

1 reference

12 December 2020

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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12 December 2020

Hydrogen peroxide mediates amyloid beta protein toxicity

1 reference

12 December 2020

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

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12 December 2020

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

12 December 2020

Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity

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12 December 2020

Amyloid beta protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease

1 reference

12 December 2020

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1 reference

12 December 2020

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

1 reference

12 December 2020

Human fetal extremity lengths in the interval from 9 to 21 menstrual weeks of pregnancy

1 reference

12 December 2020

Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons

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12 December 2020

Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: association with pathology

1 reference

12 December 2020

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production

1 reference

12 December 2020

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

1 reference

12 December 2020

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL.

1 reference

12 December 2020

DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay.

1 reference

12 December 2020

Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity

1 reference

12 December 2020

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

12 December 2020

Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family.

1 reference

12 December 2020

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

12 December 2020

10.1523/JNEUROSCI.16-23-07533.1996

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6579094&resulttype=core&format=json

15 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6579094&resulttype=core&format=json

15 May 2020

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