Assessment of frequency dependency of the class III effects of almokalant: a study using programmed stimulation and recording of monophasic action potentials and ventricular paced QT intervals (Q71847545)

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scientific article published on 01 November 1996

Language	Label	Description	Also known as
English	Assessment of frequency dependency of the class III effects of almokalant: a study using programmed stimulation and recording of monophasic action potentials and ventricular paced QT intervals	scientific article published on 01 November 1996

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8950068%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

Assessment of frequency dependency of the class III effects of almokalant: a study using programmed stimulation and recording of monophasic action potentials and ventricular paced QT intervals (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8950068%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

author name string

B Darpö

1

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21 October 2019

O Almgren

2

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21 October 2019

R Bergstrand

3

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21 October 2019

S Franzén

4

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21 October 2019

N Edvardsson

5

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21 October 2019

publication date

1 November 1996

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21 October 2019

Cardiovascular Drugs and Therapy

1 reference

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21 October 2019

10

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21 October 2019

5

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21 October 2019

539-547

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21 October 2019

Frequency-dependent effects of quinidine on the ventricular action potential and QRS duration in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequency-dependent effects of E-4031, almokalant, dofetilide and tedisamil on action potential duration: no evidence for "reverse use dependent" block

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use-dependent block and use-dependent unblock of the delayed rectifier K+ current by almokalant in rabbit ventricular myocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrophysiological and inotropic effects of H 234/09 (almokalant) in vitro: a comparison with two other novel IK blocking drugs, UK-68,798 (dofetilide) and E-4031

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

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Clinical electrophysiologic study of antiarrhythmic properties of flecainide: acute intraventricular delayed conduction and prolonged repolarization in regular paced and premature beats using intracardiac monophasic action potentials with programmed

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of almokalant, a selective potassium channel blocker, on the termination and inducibility of paroxysmal supraventricular tachycardias: a study in patients with Wolff-Parkinson-White syndrome and atrioventricular nodal reentrant tachycardia. A

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use-dependent block of the delayed K+ current in rabbit ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrical restitution in the endocardium of the intact human right ventricle

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective Ik blocker almokalant exhibits class III--specific effects on the repolarization and refractoriness of the human heart: a study of healthy volunteers using right ventricular monophasic action potential recordings

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ventricular Paced QT Interval-The Effects of Rate and Exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rate-dependent effects of sematilide on action potential duration in isolated guinea pig ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequency-dependent effects of antiarrhythmic drugs on action potential duration and refractoriness of canine cardiac Purkinje fibers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolonged Action Potential Duration and Positive Inotropy Induced by the Novel Class III Antiarrhythmic Agent H 234/09 (Almokalant) in Isolated Human Ventricular Muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of delayed repolarization during chronic beta-receptor blockade

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attenuation of proarrhythmias related to delayed repolarization by low-dose lidocaine in the anesthetized rabbit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarisations

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of dofetilide on cardiac repolarization in patients with ventricular tachycardia. A study using simultaneous monophasic action potential recordings from two sites in the right ventricle

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dispersion of monophasic action potential duration: demonstrable in humans after premature ventricular extrastimulation but not in steady state

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Class III antiarrhythmic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of the new class III antiarrhythmic agents almokalant, E-4031 and D-sotalol, and of quinidine, on delayed rectifier currents in guinea pig ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrophysiologic and Hemodynamic Effects of H 234/09 (Almokalant), Quinidine, and (+)-Sotalol in the Anesthetized Dog

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reverse use-dependent effects of sotalol demonstrated by recording monophasic action potentials of the right ventricle

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electropharmacologic effects and pharmacokinetics of almokalant, a new class III antiarrhythmic, in patients with healed or healing myocardial infarcts and complex ventricular arrhythmias

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tolerance and effects of almokalant, a new selective Ik blocking agent, on ventricular repolarization and on sino-atrial and atrioventricular nodal function in the heart: a study in healthy, male volunteers utilizing transesophageal atrial stimulati

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of E-4031, almokalant and tedisamil on postrest action potential duration of human papillary muscles

1 reference

https://pubmed.ncbi.nlm.nih.gov/8950068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00050994

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8950068%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8950068%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

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