The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme (Q71958811)

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22 October 2019

title

The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme (English)

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22 October 2019

author name string

Curnow KM

1

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22 October 2019

Mulatero P

2

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22 October 2019

Emeric-Blanchouin N

3

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22 October 2019

Aupetit-Faisant B

4

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22 October 2019

Corvol P

5

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22 October 2019

Pascoe L

6

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22 October 2019

publication date

1 January 1997

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Nature structural biology

22 October 2019

published in

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22 October 2019

volume

4

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22 October 2019

issue

1

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22 October 2019

page(s)

32-35

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The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

22 October 2019

cites work

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High-resolution crystal structure of cytochrome P450cam

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Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

31 March 2020

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Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution

31 March 2020

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Structure of cytochrome P450eryF involved in erythromycin biosynthesis

31 March 2020

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Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism

31 March 2020

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The Product of the CYP11B2 Gene Is Required for Aldosterone Biosynthesis in the Human Adrenal Cortex

31 March 2020

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A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension

31 March 2020

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Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2

31 March 2020

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Defective fasciculata zone function as the mechanism of glucocorticoid-remediable aldosteronism

31 March 2020

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Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree

31 March 2020

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Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase

31 March 2020

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The chimeric gene linked to glucocorticoid-suppressible hyperaldosteronism encodes a fused P-450 protein possessing aldosterone synthase activity

31 March 2020

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Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency

31 March 2020

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Haplotype analysis of CYP11B2

31 March 2020

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Molecular cloning and expression of cDNAS encoding rat aldosterone synthase: variants of cytochrome P-450(11 beta)

31 March 2020

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Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids

31 March 2020

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Expression of two kinds of cytochrome P-450(11 beta) mRNA in bovine adrenal cortex

31 March 2020

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Cloning and expression of cytochrome P450(11 beta) of porcine adrenal cortex

31 March 2020

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Cloning and expression analysis of a cytochrome P-450(11 beta) cDNA in sheep

31 March 2020

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Frog cytochrome P-450 (11 beta,aldo), a single enzyme involved in the final steps of glucocorticoid and mineralocorticoid biosynthesis

31 March 2020

1 reference

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P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed in a tissue-specific, developmentally, and hormonally regulated fashion in the rodent adrenal and encodes a protein with both 11-hydroxylase and 18-hydroxylase activities

31 March 2020

1 reference

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31 March 2020

Identifiers

DOI

10.1038/NSB0197-32

1 reference

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22 October 2019

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