Heparin promotes proteolytic inactivation by thrombin of a reactive site mutant (L444R) of recombinant heparin cofactor II (Q71973593)

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22 October 2019

title

Heparin promotes proteolytic inactivation by thrombin of a reactive site mutant (L444R) of recombinant heparin cofactor II (English)

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22 October 2019

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A V Ciaccia

1

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22 October 2019

A J Willemze

series ordinal

2

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22 October 2019

F C Church

series ordinal

3

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22 October 2019

language of work or name

English

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publication date

1 January 1997

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Journal of Biological Chemistry

22 October 2019

published in

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22 October 2019

volume

272

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22 October 2019

issue

2

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22 October 2019

page(s)

888-893

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Human plasma proteinase inhibitors

22 October 2019

cites work

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21 January 2018

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Heparin cofactor II and thrombin Heparin-binding proteins linking hemostasis and inflammation

21 January 2018

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Structural evidence for leucine at the reactive site of heparin cofactor II

21 January 2018

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The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

21 January 2018

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Characterization of recombinant heparin cofactor II expressed in insect cells

21 January 2018

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Reactive site mutants of recombinant protein C inhibitor

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The contribution of the conserved hinge region residues of alpha1-antitrypsin to its reaction with elastase

21 January 2018

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Decreased binding of heparin to antithrombin following the interaction between antithrombin and thrombin

21 January 2018

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Slow, spontaneous dissociation of the antithrombin-thrombin complex produces a proteolytically modified form of the inhibitor.

21 January 2018

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Transmission of conformational change from the heparin binding site to the reactive center of antithrombin

21 January 2018

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Characterization of the P2' and P3' specificities of thrombin using fluorescence-quenched substrates and mapping of the subsites by mutagenesis

21 January 2018

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Isolation and characterization of a partial cDNA clone for heparin cofactor II1.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.272.2.888

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8995378%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

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