MCF-7 breast cancer cells overexpressing transfected c-erbB-2 have an in vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivity in vivo (Q71989512)

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scientific article published on 01 May 1995

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English	MCF-7 breast cancer cells overexpressing transfected c-erbB-2 have an in vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivity in vivo	scientific article published on 01 May 1995

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scholarly article

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22 October 2019

MCF-7 breast cancer cells overexpressing transfected c-erbB-2 have an in vitro growth advantage in estrogen-depleted conditions and reduced estrogen-dependence and tamoxifen-sensitivity in vivo (English)

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22 October 2019

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author name string

Y Liu

1

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D el-Ashry

2

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D Chen

3

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22 October 2019

I Y Ding

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F G Kern

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publication date

1 May 1995

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22 October 2019

Breast Cancer Research and Treatment

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22 October 2019

34

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97-117

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22 October 2019

https://scigraph.springernature.com/pub.10.1007/bf00665783

0 references

An alternatively processed mRNA from the avian c-erbB gene encodes a soluble, truncated form of the receptor that can block ligand-dependent transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progression of human breast cancer cells from hormone-dependent to hormone-independent growth both in vitro and in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of an anti-p185HER2 monoclonal antibody that stimulates receptor function and inhibits tumor cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor inhibits growth of A431 human epidermoid carcinoma in serum-free cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of normal and malignant breast epithelial growth regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An antigen immunologically related to the external domain of gp185 is shed from nude mouse tumors overexpressing the c-erbB-2 (HER-2/neu) oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between c-erbB-2 protein product expression and response to endocrine therapy in advanced breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tamoxifen up-regulates c-erbB-2 expression in oestrogen-responsive breast cancer cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic potential of erbB-2 in human mammary epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand-independent tyrosine phosphorylation of EGF receptor and the erbB-2/neu proto-oncogene product is induced by hyperosmotic shock.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A soluble protein related to the HER-2 proto-oncogene product is released from human breast carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence of amplification of the oncogenes c-myc, HER2/neu, and int-2 in one thousand human breast tumours: correlation with steroid receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and interpretation of epidermal growth factor and c-erbB-2 overexpression

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low metastatic potential of clone from murine colon adenocarcinoma 26 increased by transfection of activated c-erbB-2 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogenic regulation of growth and polypeptide growth factor secretion in human breast carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emergence of MCF-7 cells overexpressing a transfected epidermal growth factor receptor (EGFR) under estrogen-depleted conditions: evidence for a role of EGFR in breast cancer growth and progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer cell structure: actin changes in tumour cells--possible mechanisms for malignant tumour formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additive effects of c-erbB-2, c-Ha-ras, and transforming growth factor-alpha genes on in vitro transformation of human mammary epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of epidermal growth factor-related polypeptides by 17 beta-estradiol in MCF-7 human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand and p185c-neu density govern receptor interactions and tyrosine kinase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-erbB-2 oncogene as a prognostic marker in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal-growth-factor receptors and oestrogen receptors in human breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and expression of an additional epidermal growth factor receptor-related gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-efficiency transformation of mammalian cells by plasmid DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibroblast growth factor 4 transfection of MCF-7 cells produces cell lines that are tumorigenic and metastatic in ovariectomized or tamoxifen-treated athymic nude mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neu oncogene encodes an epidermal growth factor receptor-related protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of c-erbB-2 oncogene expression by estrogens in human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of specific protein tyrosine phosphatases in human breast epithelial cells neoplastically transformed by the neu oncogene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-alpha expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-alpha complementary

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagen-induced morphogenesis and expression of the alpha 2-integrin subunit is inhibited in c-erbB2-transfected human mammary epithelial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hormonal modulation of HER-2/neu protooncogene messenger ribonucleic acid and p185 protein expression in human breast cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of tyrosine kinase activity of the epidermal growth factor (EGF) receptor by a truncated receptor form that binds to EGF: role for interreceptor interaction in kinase regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

17 alpha-Estradiol is a biologically active estrogen in human breast cancer cells in tissue culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human breast carcinoma cells in continuous culture: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of activated rat neu oncogene is sufficient to induce experimental metastasis in 3T3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical evaluation of c-erbB-2 oncogene expression in ductal carcinoma in situ and atypical ductal hyperplasia of the breast

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of heregulin, a specific activator of p185erbB2

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A ligand for the erbB-2 oncogene product (gp30) induces differentiation of human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adaptation of estrogen-dependent MCF-7 cells to low estrogen (phenol red-free) culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presence of c-erbB-2 gene product-related protein in culture medium conditioned by breast cancer cell line SK-BR-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/7647336

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00665783

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7647336%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7647336%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

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