Evidence for an interaction between the beta-blocker pafenolol and bile salts in the intestinal lumen of the rat leading to dose-dependent oral absorption and double peaks in the plasma concentration-time profile (Q72224107)

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scientific article published on 01 June 1993

Language	Label	Description	Also known as
English	Evidence for an interaction between the beta-blocker pafenolol and bile salts in the intestinal lumen of the rat leading to dose-dependent oral absorption and double peaks in the plasma concentration-time profile	scientific article published on 01 June 1993

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scholarly article

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8100633%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

Evidence for an interaction between the beta-blocker pafenolol and bile salts in the intestinal lumen of the rat leading to dose-dependent oral absorption and double peaks in the plasma concentration-time profile (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8100633%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

author name string

H Lennernäs

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8100633%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

C G Regårdh

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8100633%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

publication date

1 June 1993

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8100633%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8100633%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

10

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8100633%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

6

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8100633%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

879-883

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8100633%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

Transit of pharmaceutical dosage forms through the small intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of pafenolol in the rat: a suitable model for studying absorption mechanisms of a drug exhibiting unusual absorption properties in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional gastrointestinal absorption of the beta-blocker pafenolol in the rat and intestinal transit rate determined by movement of 14C-polyethylene glycol (PEG) 4000

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal absorption of drugs. III. The influence of taurocholate on the disappearance kinetics of hydrophilic and lipophilic drugs from the small intestine of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of pafenolol after i.v. and oral administration of three separate doses of different strength to man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal absorption of a beta-adrenergic blocking agent nadolol. III. Nuclear magnetic resonance spectroscopic study on nadolol-sodium cholate micellar complex and intestinal absorption of nadolol derivatives in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of drug absorption rates using a deconvolution method with nonequal sampling times

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal absorption of a beta-adrenergic blocking agent nadolol. I. Comparison of absorption behavior of nadolol with those of other beta-blocking agents in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of Surfactant Effects on Drug Absorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the kinetics of the passive and active transport mechanisms for bile acid absorption in the small intestine and colon of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the absorption of bile acids in the proximal small intestine of normo- and hyperlipidaemic subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of bile acid absorption across the unstirred water layer and brush border of the rat jejunum

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in effects on drug absorption between dihydroxy and trihydroxy bile salts

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal absorption of a beta-adrenergic blocking agents nadolol. II. Mechanism of the inhibitory effect on the intestinal absorption of nadolol by sodium cholate in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presystemic elimination of the beta-blocker pafenolol in the rat after oral and intraperitoneal administration and identification of a main metabolite in both rats and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-dependent intestinal absorption and significant intestinal excretion (exsorption) of the beta-blocker pafenolol in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of a single intravenous and oral dose of pafenolol--a beta 1-adrenoceptor antagonist with atypical absorption and disposition properties--in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rate of dissolution of griseofulvin and hexoestrol in bile salt solutions

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal Absorption of Drugs. The Influence of Mixed Micelles on on the Disappearance Kinetics of Drugs from the Small Intestine of the Rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of drugs with bile components. I. Effects of bile salts on the dissolution behavior of indomethacin and phenylbutazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of biliary enteroenterostomy on the pharmacokinetics of enterally administered cyclosporine in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologic Surface-Active Agents and Drug Absorption I: Effect of Sodium Taurodeoxycholate on Salicylate Transfer Across the Everted Rat Intestine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8100633

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1018965328626

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8100633%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8100633%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

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