Prosaposin (Q7250541)

http://www.ebi.ac.uk/interpro/protein/P07602

saposin, chordata

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07602

Amoebapore family

1 reference

Transporter Classification Database ID

1.C.35.2.1

retrieved

2 October 2019

hierarchical database ID heuristic

saposin B type domain, protein family

1 reference

Saposin B type, region 2, protein family

1 reference

Saposin A-type domain, protein family

1 reference

Saposin-like type B, region 1, protein family

1 reference

Regulation of cell proliferation and apoptosis through fibrocystin-prosaposin interaction

1 reference

13 November 2019

1 reference

13 November 2019

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

1 reference

8 April 2019

Binding and transport of gangliosides by prosaposin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

enzyme activator activity

1 reference

8 April 2019

Saposin A: second cerebrosidase activator protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

beta-galactosidase activity

1 reference

8 April 2019

Binding and transport of gangliosides by prosaposin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

1 reference

8 April 2019

Solution structure of human saposin C: pH-dependent interaction with phospholipid vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

protein homodimerization activity

1 reference

8 April 2019

Crystal structures of human saposins C andD: implications for lipid recognition and membrane interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

Binding and transport of gangliosides by prosaposin

ganglioside GM1 binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

Binding and transport of gangliosides by prosaposin

ganglioside GM2 binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

Binding and transport of gangliosides by prosaposin

ganglioside GM3 binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

Binding and transport of gangliosides by prosaposin

ganglioside GT1b binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

Binding and transport of gangliosides by prosaposin

ganglioside GP1c binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

identical protein binding

1 reference

17 October 2017

Crystal structures of human saposins C andD: implications for lipid recognition and membrane interactions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

G protein-coupled receptor binding

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

1 reference

8 April 2019

Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

integral component of membrane

1 reference

17 October 2017

Binding and transport of gangliosides by prosaposin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

Large-scale proteomics and phosphoproteomics of urinary exosomes

extracellular exosome

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

17 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

6 references

17 October 2017

Binding and transport of gangliosides by prosaposin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

17 October 2017

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

17 October 2017

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

17 October 2017

Binding and transport of gangliosides by prosaposin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

17 October 2017

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

azurophil granule membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

intracellular membrane-bounded organelle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

1 reference

17 October 2017

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

17 October 2017

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

6 references

8 April 2019

Binding and transport of gangliosides by prosaposin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

Binding and transport of gangliosides by prosaposin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

collagen-containing extracellular matrix

1 reference

8 April 2019

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

1 reference

8 April 2019

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

1 reference

8 April 2019

Binding and transport of gangliosides by prosaposin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

regulation of MAPK cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

Reduced cathepsins B and D cause impaired autophagic degradation that can be almost completely restored by overexpression of these two proteases in Sap C-deficient fibroblasts

regulation of autophagy

1 reference

8 April 2019

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

positive regulation of MAPK cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

cellular response to organic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

negative regulation of hydrogen peroxide-induced cell death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

platelet degranulation

1 reference

8 April 2019

positive regulation of catalytic activity

1 reference

17 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07602&geneProductId=UniProtKB:P07602

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

neutrophil degranulation

1 reference

8 April 2019

ganglioside GM1 transport to membrane

1 reference

8 April 2019

Binding and transport of gangliosides by prosaposin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

corneocyte development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

galactosylceramide catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

sensory perception of sound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

neuromuscular process controlling balance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

positive regulation of hydrolase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

cornified envelope assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

3 references

8 April 2019

Lysosomal processing of progranulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

8 April 2019

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07602

Gene Atlas image

PBB GE PSAP 200866 s at fs.png
732 × 530; 12 KB

0 references

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016