Receptor activity modifying protein 1 (Q7275752)

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mammalian protein found in Homo sapiens

receptor (calcitonin) activity modifying protein 1
Calcitonin-receptor-like receptor activity-modifying protein 1
receptor activity-modifying protein 1
RAMP1
CRLR activity-modifying protein 1
calcitonin receptor-like receptor activity modifying protein 1
receptor (G protein-coupled) activity modifying protein 1

Language	Label	Description	Also known as
English	Receptor activity modifying protein 1	mammalian protein found in Homo sapiens	receptor (calcitonin) activity modifying protein 1 Calcitonin-receptor-like receptor activity-modifying protein 1 receptor activity-modifying protein 1 RAMP1 CRLR activity-modifying protein 1 calcitonin receptor-like receptor activity modifying protein 1 receptor (G protein-coupled) activity modifying protein 1

Statements

1 reference

13 November 2019

UniProt protein ID

Receptor activity modifying protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O60894

RAMP domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O60894

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

coreceptor activity

determination method

1 reference

3 January 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O60894

determination method

calcitonin receptor activity

determination method

1 reference

3 January 2017

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O60894

determination method

calcitonin receptor binding

determination method

1 reference

3 January 2017

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O60894

determination method

protein binding

determination method

5 references

9 May 2019

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

9 May 2019

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

9 May 2019

Involvement of vascular endothelial growth factor signaling in CLR/RAMP1 and CLR/RAMP2-mediated pro-angiogenic effect of intermedin on human vascular endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

9 May 2019

Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

9 May 2019

The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

calcitonin gene-related peptide receptor activity

determination method

3 references

9 May 2019

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

9 May 2019

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

9 May 2019

Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

coreceptor activity

determination method

amylin receptor activity

determination method

calcitonin gene-related peptide binding

determination method

1 reference

9 May 2019

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

plasma membrane

determination method

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

9 May 2019

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

9 May 2019

Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

receptor complex

determination method

1 reference

3 January 2017

Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O60894

determination method

integral component of plasma membrane

determination method

1 reference

9 May 2019

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

intracellular anatomical structure

determination method

1 reference

3 January 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O60894

determination method

determination method

1 reference

3 January 2017

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O60894

determination method

extracellular space

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

amylin receptor complex 1

determination method

1 reference

9 May 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

CGRP receptor complex

determination method

biological process

G protein-coupled receptor signaling pathway

determination method

1 reference

3 January 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O60894

determination method

positive regulation of protein glycosylation

determination method

1 reference

9 May 2019

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

determination method

1 reference

3 January 2017

Involvement of vascular endothelial growth factor signaling in CLR/RAMP1 and CLR/RAMP2-mediated pro-angiogenic effect of intermedin on human vascular endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O60894

determination method

determination method

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O60894

determination method

protein transport

determination method

1 reference

3 January 2017

Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O60894

determination method

protein localization to plasma membrane

determination method

1 reference

3 January 2017

Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O60894

determination method

intracellular protein transport

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

calcium ion transport

determination method

1 reference

3 January 2017

Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O60894

determination method

determination method

G protein-coupled receptor signaling pathway

determination method

adenylate cyclase-activating G protein-coupled receptor signaling pathway

determination method

4 references

9 May 2019

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

9 May 2019

Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

9 May 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

9 May 2019

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

regulation of G protein-coupled receptor signaling pathway

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

receptor internalization

determination method

4 references

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

9 May 2019

Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

9 May 2019

Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

cellular response to hormone stimulus

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60894

determination method

protein localization to plasma membrane

determination method

amylin receptor signaling pathway

determination method

calcitonin gene-related peptide receptor signaling pathway

determination method

physically interacts with

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2103758

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000254661

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000254661

ENSP00000384688

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384688

ENSP00000386046

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000386046

ENSP00000386720

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000386720

PDB structure ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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