Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes (Q73082732)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9037249%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes (English)

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1 November 2019

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H K Crewe

1

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1 November 2019

S W Ellis

series ordinal

2

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1 November 2019

M S Lennard

series ordinal

3

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1 November 2019

G T Tucker

series ordinal

4

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1 November 2019

language of work or name

English

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publication date

1 January 1997

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1 November 2019

published in

Biochemical Pharmacology

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1 November 2019

volume

53

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1 November 2019

issue

2

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1 November 2019

page(s)

171-178

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A risk-benefit assessment of tamoxifen therapy

1 November 2019

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Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes

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A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity

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Interindividual variation in the isomerization of 4-hydroxytamoxifen by human liver microsomes: involvement of cytochromes P450.

7 January 2021

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The metabolism of tamoxifen by human liver microsomes is not mediated by cytochrome P450IID6

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Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s

7 January 2021

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Species differences in the covalent binding of [14C]tamoxifen to liver microsomes and the forms of cytochrome P450 involved

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Irreversible binding and metabolism of propranolol by human liver microsomes--relationship to polymorphic oxidation

7 January 2021

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Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

7 January 2021

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The expression of human cytochrome P450IA1 in the yeast Saccharomyces cerevisiae

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Characterization of the inhibition of P4501A2 by furafylline

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Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

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Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

7 January 2021

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High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat

7 January 2021

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Tolbutamide hydroxylation by human liver microsomes. Kinetic characterisation and relationship to other cytochrome P-450 dependent xenobiotic oxidations

7 January 2021

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Mephenytoin hydroxylation polymorphism: characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo

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Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

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Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme

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Inhibition of rabbit liver microsomal oxidative metabolism and substrate binding by tamoxifen and the geometric isomers of clomiphene

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Life threatening interaction between tamoxifen and warfarin

7 January 2021

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Life threatening interaction between tamoxifen and warfarin.

7 January 2021

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Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

7 January 2021

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10.1016/S0006-2952(96)00650-8

7 January 2021

Identifiers

DOI

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1 November 2019

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