Catalysis of the CC-1065 and duocarmycin DNA alkylation reaction: DNA binding induced conformational change in the agent results in activation (Q73133499)

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scientific article published on 01 February 1997

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English	Catalysis of the CC-1065 and duocarmycin DNA alkylation reaction: DNA binding induced conformational change in the agent results in activation	scientific article published on 01 February 1997

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scholarly article

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1 November 2019

Catalysis of the CC-1065 and duocarmycin DNA alkylation reaction: DNA binding induced conformational change in the agent results in activation (English)

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1 November 2019

author name string

D L Boger

1

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1 November 2019

R M Garbaccio

2

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1 November 2019

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publication date

1 February 1997

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1 November 2019

Bioorganic & Medicinal Chemistry

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1 November 2019

5

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1 November 2019

2

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1 November 2019

263-276

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1 November 2019

Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

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Duocarmycins, new antitumor antibiotics produced by Streptomyces; producing organisms and improved production

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Duocarmycin A, a new antitumor antibiotic from Streptomyces.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

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Structures of duocarmycins, novel antitumor antibiotics produced by Streptomyces sp.

1 reference

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7 January 2021

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Pyrindamycins A and B, new antitumor antibiotics

1 reference

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7 January 2021

based on heuristic

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Duocarmycins, potent antitumor antibiotics produced by Streptomyces sp. structures and chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

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CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

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The chemistry, mechanism of action and biological properties of CC-1065, a potent antitumor antibiotic

1 reference

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7 January 2021

based on heuristic

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Sequence selectivity of DNA covalent modification

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

(+)-CC-1065 produces bending of DNA that appears to resemble adenine/thymine tracts

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Determination of the structural features of (+)-CC-1065 that are responsible for bending and winding of DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

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A-tract and (+)-CC-1065-induced bending of DNA. Comparison of structural features using non-denaturing gel analysis, hydroxyl-radical footprinting, and high-field NMR

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the (+)-CC-1065-DNA adduct: critical role of ordered water molecules and implications for involvement of phosphate catalysis in the covalent reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of a 12-mer duplex d(GGCGGAGTTAGG).d(CCTAACTCCGCC) containing a highly reactive (+)-CC-1065 sequence by 1H and 31P NMR, hydroxyl-radical footprinting, and NOESY restrained molecular dynamics calculations

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

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(+)-CC-1065 as a structural probe of Mu transposase-induced bending of DNA: overcoming limitations of hydroxyl-radical footprinting

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A demonstration of the intrinsic importance of stabilizing hydrophobic binding and non-covalent van der Waals contacts dominant in the non-covalent CC-1065/B-DNA binding

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Demonstration and definition of the noncovalent binding selectivity of agents related to CC-1065 by an affinity cleavage agent: noncovalent binding coincidental with alkylation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The electrostatic potential of B-DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Acidic domains around nucleic acids

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

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1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogs of CC-1065 and the duocarmycins: synthesis and evaluation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and Properties of Substituted CBI Analogs of CC-1065 and the Duocarmycins Incorporating the 7-Methoxy-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (MCBI) Alkylation Subunit: Magnitude of Electronic Effects on the Functional Reactivit

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular basis for sequence-specific DNA alkylation by CC-1065

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

An NMR study of the covalent and noncovalent interactions of CC-1065 and DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Reversibility of the covalent reaction of CC-1065 and analogues with DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The reversible DNA-alkylating activity of duocarmycin and its analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Solution structure of the covalent duocarmycin A-DNA duplex complex

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

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Two-dimensional 1H and 31P NMR spectra and restrained molecular dynamics structure of a covalent CPI-CDPI2-oligodeoxyribonucleotide decamer complex

1 reference

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7 January 2021

based on heuristic

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Determination of the major tautomeric form of the covalently modified adenine in the (+)-CC-1065-DNA adduct by 1H and 15N NMR studies

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Interstrand cross-linking by bizelesin produces a Watson-Crick to Hoogsteen base-pairing transition region in d(CGTAATTACG)2

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2896%2900238-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Solution conformation of a bizelesin A-tract duplex adduct: DNA-DNA cross-linking of an A-tract straightens out bent DNA

1 reference

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7 January 2021

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inferred from DOI database lookup

Identifiers

10.1016/S0968-0896(96)00238-6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9061191%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9061191%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

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