Influence of P-glycoprotein on brain uptake of [18F]MPPF in rats (Q73163374)

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1 November 2019

title

Influence of P-glycoprotein on brain uptake of [18F]MPPF in rats (English)

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1 November 2019

author name string

J Passchier

1

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1 November 2019

A van Waarde

2

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1 November 2019

P Doze

3

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1 November 2019

P H Elsinga

4

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1 November 2019

W Vaalburg

5

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1 November 2019

language of work or name

English

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publication date

1 November 2000

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European Journal of Pharmacology

1 November 2019

published in

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1 November 2019

volume

407

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1 November 2019

issue

3

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1 November 2019

page(s)

273-280

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Transporting therapeutics across the blood-brain barrier

1 November 2019

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What have we learnt thus far from mice with disrupted P-glycoprotein genes?

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In vivo characterization of p-[(18)F]MPPF, a fluoro analog of WAY-100635 for visualization of 5-HT(1a) receptors

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Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

7 January 2021

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Modulation of doxorubicin concentration by cyclosporin A in brain and testicular barrier tissues expressing P-glycoprotein in rats

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Evaluation of [O-methyl-3H]WAY-100635 as an in vivo radioligand for 5-HT1A receptors in rat brain

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Quantitative autoradiographic characterisation of the binding of [3H]WAY-100635, a selective 5-HT1A receptor antagonist

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New 5-HT1A receptor antagonist: [3H]p-MPPF.

7 January 2021

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High-yield radiosynthesis and preliminary in vivo evaluation of p-[18F]MPPF, a fluoro analog of WAY-100635.

7 January 2021

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Quantitative imaging of 5-HT(1A) receptor binding in healthy volunteers with [(18)f]p-MPPF

7 January 2021

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Transmembrane aromatic amino acid distribution in P-glycoprotein. A functional role in broad substrate specificity.

7 January 2021

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Structural characteristics of compounds that modulate P-glycoprotein-associated multidrug resistance

7 January 2021

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NAN-190: agonist and antagonist interactions with brain 5-HT1A receptors

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

7 January 2021

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

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P-[18F]-MPPF: a potential radioligand for PET studies of 5-HT1A receptors in humans

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Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice

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The functional role of P-glycoprotein in the blood-brain barrier

7 January 2021

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Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT1A ligand

7 January 2021

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10.1016/S0014-2999(00)00752-4

7 January 2021

Identifiers

DOI

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1 November 2019

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