Combination of topotecan with cytarabine or etoposide in patients with refractory or relapsed acute myeloid leukemia: results of a randomized phase I/II study (Q73166093)

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scientific article published on 01 January 1999

Language	Label	Description	Also known as
English	Combination of topotecan with cytarabine or etoposide in patients with refractory or relapsed acute myeloid leukemia: results of a randomized phase I/II study	scientific article published on 01 January 1999

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10555127%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Combination of topotecan with cytarabine or etoposide in patients with refractory or relapsed acute myeloid leukemia: results of a randomized phase I/II study (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10555127%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference

based on heuristic

inferred from title

acute myeloid leukemia

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

N Vey

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10555127%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

H Kantarjian

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10555127%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

M Beran

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10555127%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

S O'Brien

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10555127%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

J Cortes

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10555127%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

C Koller

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10555127%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

E Estey

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10555127%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

publication date

1 January 1999

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10555127%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Investigational New Drugs

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10555127%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

17

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10555127%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10555127%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

89-95

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10555127%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

https://scigraph.springernature.com/pub.10.1023/a:1006271618635

0 references

Phase I and pharmacodynamic study of the topoisomerase I-inhibitor topotecan in patients with refractory acute leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Bayesian strategy for screening cancer treatments prior to phase II clinical evaluation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth of sensitive and drug-resistant human myeloid leukemia cells in SCID mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of CPT-11 in combination with other anti-cancer agents in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of Topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential administration of camptothecin and etoposide circumvents the antagonistic cytotoxicity of simultaneous drug administration in slowly growing human colon carcinoma HT-29 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of refractory AML.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topotecan, a topoisomerase I inhibitor, is active in the treatment of myelodysplastic syndrome and chronic myelomonocytic leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topotecan increases topoisomerase IIalpha levels and sensitivity to treatment with etoposide in schedule-dependent process

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental studies on biochemical modulation targeting topoisomerase I and II in human tumor xenografts in nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10555127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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