The natural osmolyte trimethylamine N-oxide (TMAO) restores the ability of mutant tau to promote microtubule assembly (Q73191410)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11078890%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

title

The natural osmolyte trimethylamine N-oxide (TMAO) restores the ability of mutant tau to promote microtubule assembly (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11078890%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

author name string

M J Smith

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11078890%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

R A Crowther

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11078890%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

M Goedert

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11078890%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

publication date

1 November 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11078890%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11078890%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

volume

484

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11078890%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11078890%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

page(s)

265-270

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11078890%20AND%20SRC:MED&resulttype=core&format=json

Tau is a candidate gene for chromosome 17 frontotemporal dementia

2 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Abnormal tau-containing filaments in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Domains of tau protein and interactions with microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Polymerization of tau peptides into fibrillar structures. The effect of FTDP-17 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Natural methylamine osmolytes, trimethylamine N-oxide and betaine, increase tau-induced polymerization of microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Phosphorylated tau can promote tubulin assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Why do some organisms use a urea-methylamine mixture as osmolyte? Thermodynamic compensation of urea and trimethylamine N-oxide interactions with protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

A naturally occurring protective system in urea-rich cells: mechanism of osmolyte protection of proteins against urea denaturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Forcing thermodynamically unfolded proteins to fold

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Chaperone-supervised conversion of prion protein to its protease-resistant form

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Manipulating the amyloid-beta aggregation pathway with chemical chaperones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Molecular flexibility in microtubule proteins: proton nuclear magnetic resonance characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902169-4

10.1016/S0014-5793(00)02169-4

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11078890%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference