Metabolism of the vitamin D analog EB1089 by cultured human cells: redirection of hydroxylation site to distal carbons of the side-chain (Q73253213)

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2 November 2019

title

Metabolism of the vitamin D analog EB1089 by cultured human cells: redirection of hydroxylation site to distal carbons of the side-chain (English)

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2 November 2019

2

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2 November 2019

author name string

V N Shankar

1

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2 November 2019

H L Makin

3

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2 November 2019

N J Schroeder

4

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2 November 2019

D J Trafford

5

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2 November 2019

A M Kissmeyer

6

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2 November 2019

M J Calverley

7

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E Binderup

8

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2 November 2019

G Jones

9

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2 November 2019

language of work or name

English

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publication date

1 March 1997

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2 November 2019

published in

Biochemical Pharmacology

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2 November 2019

volume

53

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2 November 2019

issue

6

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2 November 2019

page(s)

783-793

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The role of vitamin D in bone and intestinal cell differentiation

2 November 2019

cites work

1 reference

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Synthetic analogues of vitamin D3 with an oxygen atom in the side chain skeleton. A trial of the development of vitamin D compounds which exhibit potent differentiation-inducing activity without inducing hypercalcemia

7 January 2021

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Increased biological activity of 20-epi-1,25-dihydroxyvitamin D3 is due to reduced catabolism and altered protein binding

7 January 2021

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Further oxidation of hydroxycalcidiol by calcidiol 24-hydroxylase. A study with the mature enzyme expressed in Escherichia coli.

7 January 2021

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EB 1089, a novel vitamin D analogue, has strong antiproliferative and differentiation inducing effects on cancer cells

7 January 2021

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Effects of a new synthetic vitamin D analogue, EB1089, on the oestrogen-responsive growth of human breast cancer cells

7 January 2021

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Target cell metabolism of 1,25-dihydroxyvitamin D3 to calcitroic acid. Evidence for a pathway in kidney and bone involving 24-oxidation

7 January 2021

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Cloning and expression of cDNA encoding 25-hydroxyvitamin D3 24-hydroxylase

7 January 2021

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Different mechanisms of hydroxylation site selection by liver and kidney cytochrome P450 species (CYP27 and CYP24) involved in vitamin D metabolism

7 January 2021

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Metabolism of the vitamin D analog EB 1089: identification of in vivo and in vitro liver metabolites and their biological activities

7 January 2021

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The stereochemical configuration of the natural 1 alpha,25-dihydroxyvitamin D3-26,23-lactone

7 January 2021

1 reference

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Comparative effects of 1,25-dihydroxyvitamin D3 and EB 1089 on mouse renal and intestinal 25-hydroxyvitamin D3-24-hydroxylase.

7 January 2021

1 reference

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The 1,25-dihydroxyvitamin D3 (VD) analogues MC903, EB1089 and KH1060 activate the VD receptor: homodimers show higher ligand sensitivity than heterodimers with retinoid X receptors

7 January 2021

1 reference

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10.1016/S0006-2952(96)00815-5

7 January 2021

Identifiers

DOI

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2 November 2019

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