N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter (Q73305292)

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2 November 2019

title

N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter (English)

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2 November 2019

author name string

K R Prakash

1

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2 November 2019

A P Tamiz

2

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2 November 2019

G L Araldi

3

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2 November 2019

M Zhang

4

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2 November 2019

K M Johnson

5

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2 November 2019

A P Kozikowski

6

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2 November 2019

language of work or name

English

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publication date

1 December 1999

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Bioorganic & Medicinal Chemistry Letters

2 November 2019

published in

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2 November 2019

volume

9

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2 November 2019

issue

23

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2 November 2019

page(s)

3325-3328

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Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: a structure-activity study

2 November 2019

cites work

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Role of the aromatic group in the inhibition of phencyclidine binding and dopamine uptake by PCP analogs

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Compounds Affecting the Central Nervous System. 4. 3.beta.-Phenyltropane-2-carboxylic Esters and Analogs

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The discovery of an unusually selective and novel cocaine analog: difluoropine. Synthesis and inhibition of binding at cocaine recognition sites

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Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: evidence for an electrostatic interaction at the 2 beta-position.

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Biochemical and pharmacological characterization of [3H]GBR 12935 binding in vitro to rat striatal membranes: labeling of the dopamine uptake complex

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Potent and selective ligands for the dopamine transporter (DAT): structure-activity relationship studies of novel 4-[2-(diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues

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A review of the effects of dopaminergic agents on humans, animals, and drug-seeking behavior, and its implications for medication development. Focus on GBR 12909.

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Doses of GBR12909 that suppress cocaine self-administration in non-human primates substantially occupy dopamine transporters as measured by [11C] WIN35,428 PET scans.

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A tolerance study of single and multiple dosing of the selective dopamine uptake inhibitor GBR 12909 in healthy subjects

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Synthesis and biological properties of new 2beta-alkyl- and 2beta-aryl-3-(substituted phenyl)tropane derivatives: stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters

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Effect of cocaine and 5-HT3 receptor antagonists on 5-HT=indeced [5H]dopamine release from rat striatal synaptosomes

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Effects of acute and chronic administration of cocaine on striatal uptake, compartmentalization and release of [3H]dopamine.

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Use of identical assay conditions for cocaine analog binding and dopamine uptake to identify potential cocaine antagonists

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A multisubstrate mechanism of striatal dopamine uptake and its inhibition by cocaine

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Identifiers

DOI

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2 November 2019

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