Increased interferon-gamma (IFN-gamma), IL-10 and decreased IL-4 mRNA expression in peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE) (Q73310096)

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scientific article published on 01 December 2000

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English	Increased interferon-gamma (IFN-gamma), IL-10 and decreased IL-4 mRNA expression in peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)	scientific article published on 01 December 2000

Statements

scholarly article

1 reference

Europe PubMed Central

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2 November 2019

Increased interferon-gamma (IFN-gamma), IL-10 and decreased IL-4 mRNA expression in peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE) (English)

1 reference

Europe PubMed Central

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2 November 2019

lupus erythematosus

1 reference

based on heuristic

inferred from title

systemic lupus erythematosus

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based on heuristic

inferred from title

author name string

A Csiszár

1

1 reference

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2 November 2019

G Nagy

2

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2 November 2019

P Gergely

3

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2 November 2019

T Pozsonyi

4

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2 November 2019

E Pócsik

5

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2 November 2019

publication date

1 December 2000

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2 November 2019

Clinical and Experimental Immunology

1 reference

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2 November 2019

122

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2 November 2019

3

1 reference

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2 November 2019

464-470

1 reference

Europe PubMed Central

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2 November 2019

Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with a multispecific internal control

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of IL-1beta, IL-1 receptor antagonist and IL-10 by mononuclear cells from patients with SLE

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Towards a comprehensive view of immunoglobulin class switching

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine gene expression in mice undergoing chronic graft-versus-host disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship of interleukin-4 to isotypic distribution of anti-double-stranded DNA antibodies in systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous production of interleukin-10 by B lymphocytes and monocytes in systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell-independent and T cell-dependent B cell activation increases IFN-gamma R expression and renders B cells sensitive to IFN-gamma-mediated inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus. A potential mechanism of B lymphocyte hyperactivity and autoimmunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine gene profile in circulating blood mononuclear cells from patients with systemic lupus erythematosus: increased interleukin-2 but not interleukin-4 mRNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental therapy of systemic lupus erythematosus: the treatment of NZB/W mice with mouse soluble interferon-gamma receptor inhibits the onset of glomerulonephritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased spontaneous and lipopolysaccharide stimulated production of interleukin 8 by polymorphonuclear neutrophils of patients with active systemic lupus erythematosus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo effects of sex steroids on lymphocyte responsiveness and immunoglobulin levels in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Consistent production of a higher TH1:TH2 cytokine ratio by stimulated T cells in men compared with women

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Precultured and fresh human T-cells suppress the mitogen response of autologous lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Murine models of systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic autoimmune disease arises from polyclonal B cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Message amplification phenotyping (MAPPing): a technique to simultaneously measure multiple mRNAs from small numbers of cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-1 expression in human monocytes is transcriptionally and posttranscriptionally regulated by IL-4

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-4 gene expression in human peripheral blood mononuclear cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-10 inhibits cytokine production by activated macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated monocyte interleukin-6 (IL-6) production in immunosuppressed trauma patients. II. Downregulation by IL-4

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-10 inhibits human T cell proliferation and IL-2 production

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological properties of interleukin 10

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1 beta, interleukin-1 and interferon-gamma mRNA in the lymph nodes of lupus-prone mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the immunoglobulin dysregulation in GvH- and SLE-like diseases by the murine IL-4 receptor (IL-4-R)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biology of human TH1 and TH2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine production by phytohemagglutinin-stimulated human blood cells: effects of corticosteroids, T cell immunosuppressants and phosphodiesterase IV inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10:interferon-gamma-secreting cells in the peripheral blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monitoring urinary levels of monocyte chemotactic and activating factor reflects disease activity of lupus nephritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-10 regulation in normal subjects and patients with asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification of cytokine gene expression by competitive PCR using a colorimetric assay.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of fetal allograft survival by a hormone-controlled Th1- and Th2-type cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of interferon-gamma and interleukin-4 in murine lupus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: Increased interleukin-4 production and associated eosinophilia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-10 response abnormalities in systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular cytokine expression in whole blood preparations from normals and patients with atopic dermatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Profile of cytokine mRNA expression in peri-implantation human endometrium

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoids increase IL-10 expression in multiple sclerosis patients with acute relapse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated interleukin-10 levels correlated with disease activity in systemic lupus erythematosus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased Th1-like and increased Th2-like cells in systemic lupus erythematosus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of high-dose methylprednisolone administration on immune functions in multiple sclerosis patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Th1 (IL-2, interferon-gamma (IFN-gamma)) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE).

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preincubation of human resting T cell clones with interleukin 10 strongly enhances their ability to produce cytokines after stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum IL-6, TNFalpha, p55 srTNFalpha, p75srTNFalpha, srIL-2alpha levels and disease activity in systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of methylprednisolone on cytokine balance during cardiac surgery

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methyl-prednisolone up-regulates monocyte interleukin-10 production in stimulated whole blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sex hormones and pregnancy in rheumatoid arthritis and systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Competitor mRNA fragments for quantitation of cytokine specific transcripts in cell lysates

1 reference

https://pubmed.ncbi.nlm.nih.gov/11122256

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1046/J.1365-2249.2000.01369.X

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11122256%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11122256%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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