Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors (Q73334770)

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3 November 2019

title

Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors (English)

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3 November 2019

author name string

N Zhang

1

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3 November 2019

B Wu

2

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3 November 2019

D Powell

3

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3 November 2019

A Wissner

4

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3 November 2019

M B Floyd

5

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3 November 2019

E D Kovacs

6

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3 November 2019

L Toral-Barza

7

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3 November 2019

C Kohler

8

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3 November 2019

language of work or name

English

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publication date

1 December 2000

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Bioorganic & Medicinal Chemistry Letters

3 November 2019

published in

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3 November 2019

volume

10

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3 November 2019

issue

24

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3 November 2019

page(s)

2825-2828

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The MAPK signaling cascade

3 November 2019

cites work

1 reference

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7 January 2021

How MAP kinases are regulated

1 reference

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7 January 2021

Mitogen-activated protein kinases: specific messages from ubiquitous messengers

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7 January 2021

Organization and regulation of mitogen-activated protein kinase signaling pathways

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7 January 2021

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

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7 January 2021

Transformation of mammalian cells by constitutively active MAP kinase kinase

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7 January 2021

Hyperexpression of mitogen-activated protein kinase in human breast cancer

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7 January 2021

Tumor-specific activation of mitogen-activated protein kinase in human colorectal and gastric carcinoma tissues.

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Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells

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In situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms

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7 January 2021

A synthetic inhibitor of the mitogen-activated protein kinase cascade

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

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7 January 2021

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

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7 January 2021

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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7 January 2021

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors

1 reference

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7 January 2021

Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors

1 reference

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7 January 2021

How responses get more switch-like as you move down a protein kinase cascade.

1 reference

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7 January 2021

How regulated protein translocation can produce switch-like responses

1 reference

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7 January 2021

10.1016/S0960-894X(00)00580-1

Identifiers

DOI

1 reference

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3 November 2019

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