Development of potent monoclonal antibody auristatin conjugates for cancer therapy (Q73460183)

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4 November 2019

title

Development of potent monoclonal antibody auristatin conjugates for cancer therapy (English)

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4 November 2019

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Svetlana O Doronina

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Brian E Toki

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Michael Y Torgov

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Brian A Mendelsohn

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Charles G Cerveny

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Dana F Chace

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Ron L DeBlanc

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R Patrick Gearing

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Tim D Bovee

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Clay B Siegall

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Joseph A Francisco

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Alan F Wahl

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Damon L Meyer

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Peter D Senter

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publication date

1 June 2003

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4 November 2019

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4 November 2019

volume

21

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issue

7

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4 November 2019

page(s)

778-784

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https://scigraph.springernature.com/pub.10.1038/nbt832

4 November 2019

exact match

0 references

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Improving the efficacy of antibody-based cancer therapies

1 reference

7 January 2021

Monoclonal antibodies in the treatment of malignancy: basic concepts and recent developments

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7 January 2021

Rituximab: review and clinical applications focusing on non-Hodgkin's lymphoma

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Clinical experience with edrecolomab: a monoclonal antibody therapy for colorectal carcinoma

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Untangling the ErbB signalling network

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7 January 2021

Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs

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7 January 2021

An anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia. Choice of linker

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7 January 2021

Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia.

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7 January 2021

Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates

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7 January 2021

Phase I trial of the anti-Lewis Y drug immunoconjugate BR96-doxorubicin in patients with lewis Y-expressing epithelial tumors

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7 January 2021

Eradication of large colon tumor xenografts by targeted delivery of maytansinoids

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7 January 2021

Tumor-Specific Novel Taxoid−Monoclonal Antibody Conjugates

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7 January 2021

Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity

1 reference

7 January 2021

Monoclonal antibody conjugates of doxorubicin prepared with branched peptide linkers: inhibition of aggregation by methoxytriethyleneglycol chains

1 reference

7 January 2021

Protease-mediated fragmentation of p-amidobenzyl ethers: a new strategy for the activation of anticancer prodrugs

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7 January 2021

Anticancer prodrugs for application in monotherapy: targeting hypoxia, tumor-associated enzymes, and receptors

1 reference

7 January 2021

A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: in vitro and in vivo studies

1 reference

7 January 2021

TZT-1027, an antimicrotubule agent, attacks tumor vasculature and induces tumor cell death.

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7 January 2021

A novel connector linkage applicable in prodrug design

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7 January 2021

Unraveling the role of proteases in cancer

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7 January 2021

The mammalian carboxylesterases: from molecules to functions.

1 reference

7 January 2021

In vitro and in vivo activities of monoclonal antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate

1 reference

7 January 2021

Identifiers

DOI

10.1038/NBT832

1 reference

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4 November 2019

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