Light chain of botulinum A neurotoxin expressed as an inclusion body from a synthetic gene is catalytically and functionally active (Q73482447)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11195972%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

title

Light chain of botulinum A neurotoxin expressed as an inclusion body from a synthetic gene is catalytically and functionally active (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11195972%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

author name string

S A Ahmed

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11195972%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

L A Smith

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11195972%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

publication date

1 August 2000

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11195972%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11195972%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

volume

19

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11195972%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

issue

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11195972%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

page(s)

475-487

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https://scigraph.springernature.com/pub.10.1023/a:1026549431380

4 November 2019

exact match

0 references

cites work

Enhancement of the endopeptidase activity of botulinum neurotoxin by its associated proteins and dithiothreitol

1 reference

12 December 2020

Sequence homology and structural analysis of the clostridial neurotoxins

1 reference

12 December 2020

High-level expression, purification, and characterization of recombinant type A botulinum neurotoxin light chain

1 reference

12 December 2020

Identification of an ion channel-forming motif in the primary structure of tetanus and botulinum neurotoxins

1 reference

12 December 2020

Minimal essential domains specifying toxicity of the light chains of tetanus toxin and botulinum neurotoxin type A.

1 reference

12 December 2020

Botulinum neurotoxin type A: sequence of amino acids at the N-terminus and around the nicking site

1 reference

12 December 2020

The complete amino acid sequence of the Clostridium botulinum type A neurotoxin, deduced by nucleotide sequence analysis of the encoding gene

1 reference

12 December 2020

Codon preferences in free-living microorganisms

1 reference

12 December 2020

C. botulinum neurotoxin types A and E: isolated light chain breaks down into two fragments. Comparison of their amino acid sequences with tetanus neurotoxin

1 reference

12 December 2020

Expression of tetanus toxin fragment C in E. coli: high level expression by removing rare codons

1 reference

12 December 2020

Isolated light chains of botulinum neurotoxins inhibit exocytosis. Studies in digitonin-permeabilized chromaffin cells.

1 reference

12 December 2020

Interaction of 125I-labeled botulinum neurotoxins with nerve terminals. II. Autoradiographic evidence for its uptake into motor nerves by acceptor-mediated endocytosis

1 reference

12 December 2020

Codon usage in selected AT-rich bacteria

1 reference

12 December 2020

Involvement of the constituent chains of botulinum neurotoxins A and B in the blockade of neurotransmitter release

1 reference

12 December 2020

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

12 December 2020

Separation and characterization of heavy and light chains from Clostridium botulinum type C toxin and their reconstitution

1 reference

12 December 2020

Mechanism of action of tetanus and botulinum neurotoxins

1 reference

12 December 2020

Expression and Purification of the Light Chain of Botulinum Neurotoxin A: A Single Mutation Abolishes Its Cleavage of SNAP-25 and Neurotoxicity after Reconstitution with the Heavy Chain

1 reference

12 December 2020

Removal and replacement of metal ions in metallopeptidases

1 reference

12 December 2020

Secondary structural predictions for the clostridial neurotoxins.

1 reference

12 December 2020

Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragments

1 reference

12 December 2020

Cell membrane resealing by a vesicular mechanism similar to neurotransmitter release

1 reference

12 December 2020

A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain.

1 reference

12 December 2020

Peptide substrate specificity and properties of the zinc-endopeptidase activity of botulinum type B neurotoxin

1 reference

12 December 2020

SNARE motif and neurotoxins

1 reference

12 December 2020

Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond

1 reference

12 December 2020

Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25

1 reference

12 December 2020

A role for the interchain disulfide or its participating thiols in the internalization of botulinum neurotoxin A revealed by a toxin derivative that binds to ecto-acceptors and inhibits transmitter release intracellularly

1 reference

12 December 2020

Proteolytic cleavage of synthetic fragments of vesicle-associated membrane protein, isoform-2 by botulinum type B neurotoxin

1 reference

12 December 2020

Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E

1 reference

12 December 2020

Growth of clostridia and preparation of their neurotoxins.

1 reference

12 December 2020

Intracellular targets and metalloprotease activity of tetanus and botulism neurotoxins

1 reference

12 December 2020

Calcium-regulated exocytosis is required for cell membrane resealing

1 reference

12 December 2020

Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release

1 reference

12 December 2020

Proteolysis of synthetic peptides by type A botulinum neurotoxin

1 reference

12 December 2020

Structure and function of tetanus and botulinum neurotoxins.

1 reference

12 December 2020

Mapping of protective and cross-reactive domains of the type A neurotoxin of Clostridium botulinum.

1 reference

12 December 2020

Endoproteinase activity of type A botulinum neurotoxin: substrate requirements and activation by serum albumin

1 reference

12 December 2020

Antibody mapping to domains of botulinum neurotoxin serotype A in the complexed and uncomplexed forms

1 reference

12 December 2020

Induction of an immune response by oral administration of recombinant botulinum toxin

1 reference

12 December 2020

Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis.

1 reference

12 December 2020

Role of zinc in the structure and toxic activity of botulinum neurotoxin

1 reference

12 December 2020

Production of an expression system for a synaptobrevin fragment to monitor cleavage by botulinum neurotoxin B

1 reference

12 December 2020

Crystal structure of botulinum neurotoxin type A and implications for toxicity

1 reference

12 December 2020

Development of recombinant vaccines for botulinum neurotoxin

1 reference

12 December 2020