Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin (Q73583786)

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5 November 2019

title

Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin (English)

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5 November 2019

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1

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5 November 2019

author name string

E B Nielsen

series ordinal

2

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publication date

1 July 1997

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5 November 2019

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5 November 2019

volume

28

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5 November 2019

issue

1

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5 November 2019

page(s)

63-72

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Why does epilepsy become intractable? Prevention of chronic epilepsy

5 November 2019

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The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats.

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Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.

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Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor

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The gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy

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An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels

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Increased gamma-aminobutyric acid (GABA), homocarnosine and beta-alanine in cerebrospinal fluid of patients treated with gamma-vinyl GABA (4-amino-hex-5-enoic acid)

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gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice

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Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro

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The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis

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Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations

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Modification of seizure activity by electrical stimulation. II. Motor seizure

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Gabapentin as add-on therapy for refractory partial epilepsy: results of five placebo-controlled trials

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Outcomes of add-on treatment with lamotrigine in partial epilepsy

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Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat.

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Anticonvulsant and proconvulsant effects of inhibitors of GABA degradation in the amygdala-kindling model

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7 January 2021

Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats.

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Anticonvulsant drugs and their antagonism of kindled amygdaloid seizures in rats

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7 January 2021

Production of specific antibodies against GABA transporter subtypes (GAT1, GAT2, GAT3) and their application to immunocytochemistry

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7 January 2021

Localization of [3H]gabapentin to a novel site in rat brain: autoradiographic studies.

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Kindling as a model of drug-resistant partial epilepsy: selection of phenytoin-resistant and nonresistant rats

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Identifiers

DOI

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5 November 2019

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