Route-dependent metabolism of morphine in the vascularly perfused rat small intestine preparation (Q73761274)

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6 November 2019

title

Route-dependent metabolism of morphine in the vascularly perfused rat small intestine preparation (English)

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6 November 2019

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2

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6 November 2019

author name string

M M Doherty

series ordinal

1

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6 November 2019

publication date

1 March 2000

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6 November 2019

published in

Pharmaceutical Research

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6 November 2019

volume

17

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6 November 2019

issue

3

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6 November 2019

page(s)

291-298

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3'-azido-3'-deoxythymidine drug interactions. Screening for inhibitors in human liver microsomes

6 November 2019

cites work

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12 December 2020

Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test

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Metabolism of drugs and other xenobiotics in the gut lumen and wall

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Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine.

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Viability of the vascularly perfused, recirculating rat intestine and intestine-liver preparations.

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Localization and characterization of drug-metabolizing enzymes along the villus-crypt surface of the rat small intestine--I. Monooxygenases

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Molecular and physical mechanisms of first-pass extraction

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Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine

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Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat

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12 December 2020

Localization and characterization of drug-metabolizing enzymes along the villus-crypt surface of the rat small intestine--II. Conjugases

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12 December 2020

Morphine metabolism. II. Studies on morphine glucuronyltransferase activity in intestinal microsomes of rats

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12 December 2020

Studies of the enterohepatic circulation of morphine in the rat

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12 December 2020

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

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Glucuronidation of morphine and six beta 2-sympathomimetics in isolated rat intestinal epithelial cells

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Absorption and metabolism of acetaminophen by the in situ perfused rat small intestine preparation

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12 December 2020

Glucuronidation in isolated perfused rat intestinal segments after mucosal and serosal administration of 1-naphthol

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Morphine metabolism in man

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First-pass metabolism of midazolam by the human intestine.

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Extent and implications of interspecies differences in the intestinal hydrolysis of certain glucuronide conjugates

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Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil

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Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

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12 December 2020

First-pass disposition of (-)-6-aminocarbovir in rats. I. Prodrug activation may be limited by access to enzyme

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12 December 2020

A new physiologically based, segregated-flow model to explain route-dependent intestinal metabolism.

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P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells

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Physiologically based pharmacokinetic model for digoxin distribution and elimination in the rat

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Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

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Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption.

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Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics

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Disposition of enalapril in the perfused rat intestine-liver preparation: absorption, metabolism and first-pass effect

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12 December 2020

Protein measurement with the Folin phenol reagent

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12 December 2020

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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12 December 2020

Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells.

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12 December 2020

Determination of morphine, morphine-3-glucuronide and (tentatively) morphine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography

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12 December 2020

Is the role of the small intestine in first-pass metabolism overemphasized?

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12 December 2020

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

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12 December 2020

First-pass effect: significance of the intestine for absorption and metabolism

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12 December 2020

Carrier-mediated intestinal transport of drugs

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12 December 2020

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

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12 December 2020

Glucuronidation in vitro and in vivo. Comparison of intestinal and hepatic conjugation of morphine, naloxone, and buprenorphine

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12 December 2020

Identifiers

DOI

10.1023/A:1007548905772

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6 November 2019

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