Effect of ligand binding on the flexibility of dihydrofolate reductase as revealed by compressibility (Q73822397)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10825537%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Effect of ligand binding on the flexibility of dihydrofolate reductase as revealed by compressibility (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10825537%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

author name string

T Kamiyama

series ordinal

1

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7 November 2019

K Gekko

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10825537%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

language of work or name

English

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publication date

1 May 2000

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7 November 2019

number of pages

10

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Biochimica et Biophysica Acta

inferred from page(s)

published in

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7 November 2019

volume

1478

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7 November 2019

issue

2

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7 November 2019

page(s)

257-266

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Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding

7 November 2019

cites work

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Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

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Effects of multiple replacements at a single position on the folding and stability of dihydrofolate reductase from Escherichia coli

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7 January 2021

Long-range electrostatic interactions can influence the folding, stability, and cooperativity of dihydrofolate reductase.

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7 January 2021

Transient intermediates in the folding of dihydrofolate reductase as detected by far-ultraviolet circular dichroism spectroscopy.

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7 January 2021

Dihydrofolate reductase: multiple conformations and alternative modes of substrate binding

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Evidence for two interconverting protein isomers in the methotrexate complex of dihydrofolate reductase from Escherichia coli

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7 January 2021

Dynamics of the dihydrofolate reductase-folate complex: catalytic sites and regions known to undergo conformational change exhibit diverse dynamical features

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7 January 2021

Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

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7 January 2021

Impact on catalysis of secondary structural manipulation of the alpha C-helix of Escherichia coli dihydrofolate reductase.

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7 January 2021

Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant

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7 January 2021

Effects of point mutation in a flexible loop on the stability and enzymatic function of Escherichia coli dihydrofolate reductase.

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7 January 2021

Point mutations at glycine-121 of Escherichia coli dihydrofolate reductase: important roles of a flexible loop in the stability and function

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7 January 2021

Effects of point mutations at the flexible loop glycine-67 of Escherichia coli dihydrofolate reductase on its stability and function

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7 January 2021

Effects of point mutations at the flexible loop alanine-145 of Escherichia coli dihydrofolate reductase on its stability and function

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7 January 2021

Nonadditive effects of double mutations at the flexible loops, glycine-67 and glycine-121, of Escherichia coli dihydrofolate reductase on its stability and function

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7 January 2021

The internal dynamics of globular proteins.

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7 January 2021

Thermodynamic fluctuations in protein molecules

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7 January 2021

Compressibility-structure relationship of globular proteins.

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7 January 2021

The hydration of globular proteins as derived from volume and compressibility measurements: cross correlating thermodynamic and structural data

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7 January 2021

Compactness of thermally and chemically denatured ribonuclease A as revealed by volume and compressibility

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7 January 2021

Volumetric Characterizations of the Native, Molten Globule and Unfolded States of Cytochromecat Acidic pH

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7 January 2021

Partial volumes and compressibilities of extended polypeptide chains in aqueous solution: additivity scheme and implication of protein unfolding at normal and high pressure

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7 January 2021

Adiabatic compressibility of myoglobin. Effect of axial ligand and denaturation

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7 January 2021

Characterization of tightly bound substrates in pure preparations of dihydrofolate reductase: implications for studies on enzymes

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7 January 2021

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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7 January 2021

Internal cavities and buried waters in globular proteins.

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A Functional Role for Protein Cavities in Domain:Domain Motions

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7 January 2021

Some factors in the interpretation of protein denaturation

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7 January 2021

Implications for enzymic catalysis from free-energy reaction coordinate profiles

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7 January 2021

10.1016/S0167-4838(00)00019-4

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10825537%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

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