Spontaneous hydrolysis of 4-trifluoromethylphenol to a quinone methide and subsequent protein alkylation (Q73824878)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10826650%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Spontaneous hydrolysis of 4-trifluoromethylphenol to a quinone methide and subsequent protein alkylation (English)

1 reference

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Alpha,Alpha,Alpha-Trifluoro-P-Cresol

7 November 2019

main subject

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ChEBI release 2020-05-28

D C Thompson

1

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7 November 2019

K Perera

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10826650%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

R London

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10826650%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

publication date

1 April 2000

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Chemico-biological Interactions

7 November 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10826650%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

volume

126

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7 November 2019

issue

1

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7 November 2019

page(s)

1-14

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Metabolism and cytotoxicity of eugenol in isolated rat hepatocytes

7 November 2019

cites work

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The enzymatic formation and chemical reactivity of quinone methides correlate with alkylphenol-induced toxicity in rat hepatocytes.

7 January 2021

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Cresol isomers: comparison of toxic potency in rat liver slices

7 January 2021

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Quinone methide formation from para isomers of methylphenol (cresol), ethylphenol, and isopropylphenol: relationship to toxicity

7 January 2021

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o-Methoxy-4-alkylphenols That Form Quinone Methides of Intermediate Reactivity Are the Most Toxic in Rat Liver Slices

7 January 2021

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Comparative toxicity of eugenol and its quinone methide metabolite in cultured liver cells using kinetic fluorescence bioassays

7 January 2021

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Studies on the mechanism of hepatotoxicity of 4-methylphenol (p-cresol): effects of deuterium labeling and ring substitution

7 January 2021

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The Carbon-Fluorine Bond in Compounds of Biological Interest

7 January 2021

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Effects of fluorine substitution on drug metabolism: pharmacological and toxicological implications

7 January 2021

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Ortho and para substituted derivatives of benzotrifluoride

7 January 2021

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Hydrolysis of hydroxybenzotrifluorides and fluorinated uracil derivatives. General mechanism for carbon-fluorine bond labilization

7 January 2021

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A fluorometric method for determination of oxidized and reduced glutathione in tissues

7 January 2021

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The influence of 4-alkyl substituents on the formation and reactivity of 2-methoxy-quinone methides: evidence that extended pi-conjugation dramatically stabilizes the quinone methide formed from eugenol

7 January 2021

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Inhibition of mitochondrial respiration by a para-quinone methide

7 January 2021

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Mechanism-based inactivation of prostatic acid phosphatase

7 January 2021

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4-(Fluoromethyl)phenyl Phosphate Acts as a Mechanism-based Inhibitor of Calcineurin

7 January 2021

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Mechanism-based inhibitors for the inactivation of the bacterial phosphotriesterase

7 January 2021

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Prediction of stability in pharmaceutical preparations. XV. Kinetics of hydrolysis of 5-trifluoromethyl-2'-deoxyuridine

7 January 2021

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Biological Effects of 5-Carboxy-2′-Deoxyuridine: Hydrolysis Product of 5-Trifluoromethyl-2′-Deoxyuridine

7 January 2021

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Kinetic analysis of glutathione in anchored cells with monochlorobimane

7 January 2021

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Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems

7 January 2021

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Identification of the arylazido-beta-alanyl-NAD+-modified site in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase by microsequencing and fast atom bombardment mass spectrometry

7 January 2021

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Identification of koningic acid (heptelidic acid)-modified site in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase

7 January 2021

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Inhibition of glyceraldehyde-3-phosphate dehydrogenase by pentalenolactone. 2. Identification of the site of alkylation by tetrahydropentalenolactone.

7 January 2021

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10.1016/S0009-2797(99)00162-3

7 January 2021

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10826650%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

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