Enhanced apoptosis of T cells in common variable immunodeficiency (CVID): role of defective CD28 co-stimulation (Q73873077)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10844530%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Enhanced apoptosis of T cells in common variable immunodeficiency (CVID): role of defective CD28 co-stimulation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10844530%20AND%20SRC:MED&resulttype=core&format=json

common variable immunodeficiency

7 November 2019

main subject

1 reference

1 reference

Charlotte Cunningham-Rundles

5

object named as

C Cunningham-Rundles

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10844530%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

author name string

M Di Renzo

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10844530%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Z Zhou

2

1 reference

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7 November 2019

I George

3

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7 November 2019

K Becker

4

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7 November 2019

publication date

1 June 2000

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Clinical and Experimental Immunology

7 November 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10844530%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

volume

120

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7 November 2019

issue

3

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7 November 2019

page(s)

503-511

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Three distinct stages of B-cell defects in common varied immunodeficiency.

7 November 2019

cites work

1 reference

12 December 2020

Interleukin-2 correction of defective in vitro T-cell mitogenesis in patients with common varied immunodeficiency

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Defective DNA synthesis by T cells in acquired 'common-variable' hypogammaglobulinaemia on stimulation with mitogens

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Peripheral blood lymphocytes of patients with common variable immunodeficiency (CVI) produce reduced levels of interleukin-4, interleukin-2 and interferon-gamma, but proliferate normally upon activation by mitogens

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Abnormalities of lymphokine gene expression in patients with common variable immunodeficiency.

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Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2

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IL-2 protects against anti-CD3-induced cell death in human medullary thymocytes.

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Characterization of common variable immunodeficiency: identification of a subset of patients with distinctive immunophenotypic and clinical features

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Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

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B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

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CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

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DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement

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B cells from subjects with CVI can be driven to Ig production in response to CD40 stimulation

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Immunophenotypical alterations in a subset of patients with common variable immunodeficiency (CVID)

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NIH conference. New insights into common variable immunodeficiency

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The role of the CD28 receptor during T cell responses to antigen

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The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory

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Differential T cell costimulatory requirements in CD28-deficient mice

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Activation interferes with the APO-1 pathway in mature human T cells.

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Co-stimulation with anti-CD28 (Kolt-2) enhances DNA synthesis by defective T cells in common variable immunodeficiency

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The costimulatory signal CD28 is fully functional but cannot correct the impaired antigen response in T cells of patients with common variable immunodeficiency

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Use of a flow cytometric assay to quantitate apoptosis in human lymphocytes.

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Failure in antigen responses by T cells from patients with common variable immunodeficiency (CVID).

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B cell differentiation defects in common variable immunodeficiency are ameliorated after stimulation with anti-CD40 antibody and IL-10

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The B7 and CD28 receptor families

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A defect in the early phase of T-cell receptor-mediated T-cell activation in patients with common variable immunodeficiency.

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Absence of B7-dependent responses in CD28-deficient mice

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Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response

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12 December 2020

Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division

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12 December 2020

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

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12 December 2020

B cells from a distinct subset of patients with common variable immunodeficiency (CVID) have increased CD95 (Apo-1/fas), diminished CD38 expression, and undergo enhanced apoptosis.

1 reference

12 December 2020

Activation via the antigen receptor is impaired in T cells, but not in B cells from patients with common variable immunodeficiency

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12 December 2020

CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation

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12 December 2020

Lack of specific antibody response in common variable immunodeficiency (CVID) associated with failure in production of antigen-specific memory T cells. MRC Immunodeficiency Group.

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Common variable immunodeficiency: how many diseases?

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Primary immunodeficiency diseases. Report of a WHO scientific group

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Granulomatous disease in common variable immunodeficiency

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Defective integration of activating signals derived from the T cell receptor (TCR) and costimulatory molecules in both CD4+ and CD8+ T lymphocytes of common variable immunodeficiency (CVID) patients

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In vitro cell death of activated lymphocytes in Omenn's syndrome

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Monitoring early cellular responses in apoptosis is aided by the mitochondrial membrane protein-specific monoclonal antibody APO2.7.

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12 December 2020

Primary defect in CD8+ lymphocytes in the antibody deficiency disease (common variable immunodeficiency): abnormalities in intracellular production of interferon-gamma (IFN-gamma) in CD28+ ('cytotoxic') and CD28- ('suppressor') CD8+ subsets.

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12 December 2020

IL-10 production in common variable immunodeficiency

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12 December 2020

The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NF-AT.

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12 December 2020

CD95 expression and function on lymphocyte subpopulations in common variable immunodeficiency (CVID); related to increased apoptosis

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12 December 2020

Common variable immunodeficiency: clinical and immunological features of 248 patients.

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12 December 2020