Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway (Q73977274)

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8 November 2019

title

Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway (English)

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8 November 2019

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A C Maroney

1

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M A Glicksman

2

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A N Basma

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K M Walton

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E Knight

5

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C A Murphy

6

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B A Bartlett

7

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J P Finn

8

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T Angeles

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Y Matsuda

10

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N T Neff

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C A Dionne

12

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8 November 2019

publication date

1 January 1998

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8 November 2019

published in

Journal of Neuroscience

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volume

18

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issue

1

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8 November 2019

page(s)

104-111

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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

8 November 2019

cites work

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Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

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Skeletal muscle-derived trophic factors prevent motoneurons from entering an active cell death program in vitro.

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K-252a and staurosporine promote choline acetyltransferase activity in rat spinal cord cultures

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Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones.

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Medial septal cholinergic neurons express c-Jun but do not undergo DNA fragmentation after fornix-fimbria transections.

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Programmed cell death in the absence of c-Fos and c-Jun

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ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons

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c-Jun NH2-terminal kinase-mediated activation of interleukin-1beta converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis

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Differential effects of the protein kinase inhibitor K-252a on the in vitro survival of chick embryonic neurons

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K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

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K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells.

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Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors

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Neutralizing anti-p21ras Fabs suppress rat sympathetic neuron survival induced by NGF, LIF, CNTF and cAMP

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Effect of 1-beta-D-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM67).

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Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

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12 December 2020

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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12 December 2020

Embryonic development of four different subsets of cholinergic neurons in rat cervical spinal cord

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The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

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Motoneurons deprived of trophic support in vitro require new gene expression to undergo programmed cell death.

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

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The stress-activated protein kinase subfamily of c-Jun kinases

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12 December 2020

Inhibition of p42 and p44 mitogen-activated protein kinase activity by PD98059 does not suppress nerve growth factor-induced survival of sympathetic neurones

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12 December 2020

Assay of myosin light chain kinase activity by high-performance liquid chromatography using a synthetic peptide as substrate

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12 December 2020

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

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12 December 2020

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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12 December 2020

Growth of a rat neuroblastoma cell line in serum-free supplemented medium

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12 December 2020

Enzyme-linked immunosorbent assay for trkA tyrosine kinase activity

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12 December 2020

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

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12 December 2020

A rapid fluorometric assay to measure neuronal survival in vitro

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12 December 2020

MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases?

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12 December 2020

Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives

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Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

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12 December 2020

GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle

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12 December 2020

Generation patterns of four groups of cholinergic neurons in rat cervical spinal cord: a combined tritiated thymidine autoradiographic and choline acetyltransferase immunocytochemical study

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12 December 2020

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

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12 December 2020

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

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12 December 2020

Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose.

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12 December 2020

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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12 December 2020

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

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12 December 2020

Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons.

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12 December 2020

Cell death during development of the nervous system

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12 December 2020

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

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12 December 2020

Inhibition of p38 mitogen-activated protein kinase by insulin in cultured fetal neurons

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12 December 2020

Fibroblast growth factor-2 suppression of tumor necrosis factor alpha-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase

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12 December 2020

p21ras supports the survival of chick embryonic motor neurones

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12 December 2020

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

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12 December 2020

Neurotrophins promote motor neuron survival and are present in embryonic limb bud.

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12 December 2020

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

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12 December 2020

K-252a promotes survival and choline acetyltransferase activity in striatal and basal forebrain neuronal cultures

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Members of several gene families influence survival of rat motoneurons in vitro and in vivo.

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12 December 2020

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling

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12 December 2020

10.1523/JNEUROSCI.18-01-00104.1998

Identifiers

DOI

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