The L5178Y/tk+/- mouse lymphoma specific gene and chromosomal mutation assay a phase III report of the U.S. Environmental Protection Agency Gene-Tox Program (Q74063591)

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scientific article published on 01 November 1997

Language	Label	Description	Also known as
English	The L5178Y/tk+/- mouse lymphoma specific gene and chromosomal mutation assay a phase III report of the U.S. Environmental Protection Agency Gene-Tox Program	scientific article published on 01 November 1997

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scholarly article

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8 November 2019

The L5178Y/tk+/- mouse lymphoma specific gene and chromosomal mutation assay a phase III report of the U.S. Environmental Protection Agency Gene-Tox Program (English)

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8 November 2019

environmental protection

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A D Mitchell

1

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8 November 2019

A E Auletta

2

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8 November 2019

D Clive

3

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8 November 2019

P E Kirby

4

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8 November 2019

M M Moore

5

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8 November 2019

B C Myhr

6

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8 November 2019

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1 November 1997

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8 November 2019

Mutation Research

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8 November 2019

394

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8 November 2019

1-3

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8 November 2019

177-303

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8 November 2019

Comparative mutagenicity testing of bropirimine, 1. Induction of chromosome aberrations in CHO cells is not reflected in induction of mutation at the TK locus of L5178Y cells

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Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells. I. Application to genetic toxicological testing

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7 January 2021

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Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells. II. Test validation and interpretation.

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7 January 2021

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The metabolism of N-acetyl-2-aminofluorene to a mutagen in L5178Y/TK+/− mouse lymphoma cells

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7 January 2021

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Preclinical toxicology studies with azithromycin: genetic toxicology evaluation.

1 reference

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7 January 2021

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Induction of trifluorothymidine-resistant mutants by metal ions in L5178Y/TK+/- cells

1 reference

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7 January 2021

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Ascorbate is detectably mutagenic in the L5178Y TK+/- cell mutation assay

1 reference

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7 January 2021

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The activation of procarcinogens to mutagens by cultured rat hepatocytes in the L5178Y/TK mutation assay

1 reference

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7 January 2021

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Promutagen activation by rodent-liver postmitochondrial fractions in the L5178Y/TK cell mutation assay

1 reference

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7 January 2021

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Mutagenic evaluation of carcinogens and non-carcinogens in the L5178Y/TK assay utilizing postmitochondrial fractions (S9) from normal rat liver

1 reference

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7 January 2021

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The mutagenicity of 5-azacytidine and other inhibitors of replicative DNA synthesis in the L5178Y mouse lymphoma cell

1 reference

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7 January 2021

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Chromosome aberration and sister chromatid exchange test results with 42 chemicals.

1 reference

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7 January 2021

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Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells

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7 January 2021

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Evaluation of ochratoxin A for mutagenicity in a battery of bacterial and mammalian cell assays.

1 reference

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Mutagenicity of chloropropanol in a genetic screening battery.

1 reference

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7 January 2021

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Chromosome analysis of trifluorothymidine-resistant L5178Y mouse lymphoma cell colonies

1 reference

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7 January 2021

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Genotoxic effects in cultured mammalian cells produced by low pH treatment conditions and increased ion concentrations.

1 reference

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Genetic screening of compounds used in drug abuse treatment. II. Methadone

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7 January 2021

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Genetic screening of compounds used in drug abuse treatment. III. LAAM.

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7 January 2021

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Genotoxicity of theobromine in a series of short-term assays

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7 January 2021

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Mutagenic activity of 27 dyes and related chemicals in the salmonella/microsome and mouse lymphoma TK+/- assays.

1 reference

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7 January 2021

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Mutagenic activity of 5 thiazole compounds in the Salmonella/microsome and mouse lymphoma TK+/- assays.

1 reference

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7 January 2021

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Genotoxicity of multifunctional acrylates in the Salmonella/mammalian-microsome assay and mouse lymphoma TK+/-assay

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7 January 2021

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Genotoxic potential of acephate technical: in vitro and in vivo effects.

1 reference

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7 January 2021

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The potent hepatocarcinogen methapyrilene induces mutations in L5178Y mouse lymphoma cells in the apparent absence of DNA adduct formation

1 reference

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7 January 2021

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The mutagenic activity of selected compounds at the TK locus: rodent vs. human cells

1 reference

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7 January 2021

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Mutagenicity of methylisocyanate and its reaction products to cultured mammalian cells.

1 reference

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7 January 2021

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Mutagenic activity of fluorides in mouse lymphoma cells

1 reference

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7 January 2021

based on heuristic

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A mutational assay system using the thymidine kinase locus in mouse lymphoma cells

1 reference

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7 January 2021

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Mutagenicity of 2-amino-N6-hydroxyadenine (AHA) at three loci in L5178Y/tk± mouse lymphoma cells: molecular and preliminary cytogenetic characterizations of AHA-induced tk−/− mutants

1 reference

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7 January 2021

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Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay system

1 reference

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7 January 2021

based on heuristic

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Specific gene mutations in L5178Y cells in culture.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Laboratory procedure for assessing specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells

1 reference

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7 January 2021

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Preclinical toxicology studies with acyclovir: genetic toxicity tests

1 reference

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7 January 2021

based on heuristic

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Procarbazine is a potent mutagen at the heterozygous thymidine kinase (tk +/-) locus of mouse lymphoma assay

1 reference

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7 January 2021

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A comparison of the agar cloning and microtitration techniques for assaying cell survival and mutation frequency in L5178Y mouse lymphoma cells.

1 reference

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Comparative induction of gene mutations and chromosome damage by 1-methoxy-1,3,5-cycloheptatriene (MCHT), 2. Results using L5178Y mouse lymphoma cells to detect both gene and chromosome damage; validation with ionizing radiation, methyl methanesulph

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1 reference

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7 January 2021

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The mutagenicity of 2-amino-N6-hydroxyadenine to L5178Y tk +/- 3.7.2C mouse lymphoma cells: measurement of mutations to ouabain, 6-thioguanine and trifluorothymidine resistance, and the induction of micronuclei

1 reference

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7 January 2021

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Locus specificity of mutagenicity of 2,4-diaminotoluene in both L5178Y mouse lymphoma and AT3-2 Chinese hamster ovary cells

1 reference

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7 January 2021

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Analysis of the genotoxicity of nine acrylate/methacrylate compounds in L5178Y mouse lymphoma cells.

1 reference

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7 January 2021

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Mutagenicity and clastogenicity of teniposide (VM-26) in L5178Y/TK +/- -3.7.2C mouse lymphoma cells

1 reference

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7 January 2021

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Mutagenicity of actinomycin D in mammalian cells due to clastogenic effects

1 reference

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7 January 2021

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Mutagenicity and clastogenicity of proflavin in L5178Y/TK +/- -3.7.2.C cells

1 reference

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7 January 2021

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1 reference

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7 January 2021

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Micronucleus, chromosome aberration, and small-colony TK mutant analysis to quantitate chromosomal damage in L5178Y mouse lymphoma cells

1 reference

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7 January 2021

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1 reference

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7 January 2021

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1 reference

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1 reference

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Bromodeoxyuridine resistance induced in mouse lymphoma cells by microsomal activation of dimethylnitrosamine

1 reference

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Mutagenic activity of some coffee flavor ingredients.

1 reference

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1 reference

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1 reference

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7 January 2021

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Absence of mutagenic activity for monosodium cyanurate.

1 reference

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7 January 2021

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1 reference

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7 January 2021

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1 reference

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7 January 2021

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1 reference

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7 January 2021

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1 reference

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7 January 2021

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1 reference

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7 January 2021

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Evaluation of di‐(2‐ethylhexyl)phthalate and its major metabolites in the ames test and L5178Y mouse lymphoma mutagenicity assay

1 reference

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7 January 2021

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1 reference

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7 January 2021

based on heuristic

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1 reference

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7 January 2021

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Mutagenic activity of acrylamide in eukaryotic systems but not in bacteria.

1 reference

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7 January 2021

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Mutagenicity of methyl bromide in a series of short-term tests.

1 reference

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7 January 2021

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Mathematical model of L5178Y mouse lymphoma forward mutation assay.

1 reference

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7 January 2021

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Mutagenicity studies on FD&C red No.3.

1 reference

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7 January 2021

based on heuristic

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mutagenicity tests of diflubenzuron in the micronucleus test in mice, the L5178Y mouse lymphoma forward mutation assay, and the Ames Salmonella reverse mutation test

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Development of an optimal S9 activation mixture for the L5178Y TK+/- mouse lymphoma mutation assay

1 reference

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7 January 2021

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The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program

1 reference

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7 January 2021

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Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. II: 18 coded chemicals

1 reference

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7 January 2021

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Responses of the L5178Y mouse lymphoma forward mutation assay: V. Gases and vapors

1 reference

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7 January 2021

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TFT and 6TG resistance of mouse lymphoma cells to analogs of azacytidine.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Responses of the L5178Y mouse Lymphoma cell forward mutation assay. V: 27 coded chemicals

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Studies of an S9-based metabolic activation system used in the mouse lymphoma L5178Y cell mutation assay

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I: Results for nine compounds

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Reactivity of catecholamines and related substances in the mouse lymphoma L5178Y cell assay for mutagens.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

An evaluation of the genotoxic potential of di-isononyl adipate

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The genetic toxicity of 1,2-dibromo-3-chloropropane, 1,2-dibromo-3-chloro-2-methylpropane, and 1,2,3-tribromo-2-methylpropane

1 reference

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7 January 2021

based on heuristic

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Activity of the plant flavanol quercetin in the mouse lymphoma L5178Y TK+/- mutation, DNA single-strand break, and Balb/c 3T3 chemical transformation assays

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Evaluation of the effect of agar on the results obtained in the L5178Y mouse lymphoma assay

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic toxicity of dopamine.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mutagenicity and clastogenicity of acrylamide in L5178Y mouse lymphoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Genotoxicity of acrylic acid, methyl acrylate, ethyl acrylate, methyl methacrylate, and ethyl methacrylate in L5178Y mouse lymphoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

High concentrations of sodium chloride induce a “positive” response at the tk locus of l5178y/tk± mouse lymphoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutagenicity and clastogenicity of adriamycin in L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutagenesis of L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells by the clastogen ellipticine

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The quantitation of TK-/- and HGPRT- mutants of L5178Y/TK+/- mouse lymphoma cells at varying times post-treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The utilization of trifluorothymidine (TFT) to select for thymidine kinase-deficient (TK-/-) mutants from L5178Y/TK+/- mouse lymphoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential mutant quantitation at the mouse lymphoma tk and CHO hgprt loci

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Genotoxicity of 2-amino-6-N-hydroxyadenine (AHA) to mouse lymphoma and CHO cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantitation of small colony trifluorothymidine-resistant mutants of L5178Y/TK+/- mouse lymphoma cells in RPMI-1640 medium.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: Results for 31 coded compounds in the national toxicology program

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

L5178Y mouse lymphoma cell mutation assay results with 41 compounds.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Chemical carcinogens. A review and analysis of the literature of selected chemicals and the establishment of the Gene-Tox Carcinogen Data Base. A report of the U.S. Environmental Protection Agency Gene-Tox Program

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

An evaluation of the L5178Y TK+/- mouse lymphoma forward mutation assay using 42 chemicals

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2. III. Effects in the Salmonella typhimurium/Escherichia coli reversion assay and the mouse lymphoma L5178Y TK+/- forward mutation assay

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

A comparison of the CHO/HGPRT+ and the L5178Y/TK+/- mutation assays using suspension treatment and soft agar cloning: results for 10 chemicals.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutagenicity of metal salts in the L5178Y mouse lymphoma assay

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutagenicity studies on ketone solvents: methyl ethyl ketone, methyl isobutyl ketone, and isophorone

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Induced hepatocytes as a metabolic activation system for the mouse-lymphoma assay

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic toxicity evaluation of McN-5195: a novel analgesic.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Genotoxic properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU).

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutagenicity studies of R-amino salt, a metabolite of amaranth (FD & C Red No. 2), in mouse lymphoma cells heterozygous at the thymidine kinase locus and in the rat dominant lethal test

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutagenicity of maleic acid hydrazide for the TK locus of mouse lymphoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Genotoxicity testing: current practices and strategies used by the pharmaceutical industry

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The genotoxicity of trenbolone, a synthetic steroid.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Genotoxicity of 6 oxime compounds in the salmonella/mammalian-microsome assay and mouse lymphoma TK +/- assay.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Evaluation of diallate and triallate herbicides for genotoxic effects in a battery of in vitro and short-term in vivo tests

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutagenic response of mouse lymphoma cells after activation of benzidine and 2-aminofluorene with purified prostaglandin H synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The genetic toxicology of Kathon biocide, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Chromosome maps of man and mouse. IV.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Activity of bromochlorodifluoromethane (BCF) in three mutation tests

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Lack of genotoxicity with acrylate polymers in five short-term mutagenicity assays.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutagenicity of alkyl glycidyl ethers in three short-term assays.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutagenicity testing of diethylene glycol monobutyl ether

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Genotoxicity of zinc in 4 short-term mutagenicity assays

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Lack of genotoxicity of cross-linked acrylate polymers in four short-term genotoxicity assays.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The effect of liver homogenate (S20) concentration on polycyclic aromatic hydrocarbon activation and mutation induction in the L5178Y mouse lymphoma mutation assay.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Methapyrilene is a genotoxic carcinogen: studies on methapyrilene and pyrilamine in the L5178Y/TK +/- mouse lymphoma assay.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mouse lymphoma L5178Y thymidine kinase locus assay of 50 compounds

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The genetic toxicology of Gene-Tox non-carcinogens

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: confirmation of earlier results with 41 additional chemicals

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5718%2897%2900115-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1383-5718(97)00115-0

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9434856%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9434856%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

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