Two transport binding sites of P-glycoprotein are unequal yet contingent: initial rate kinetic analysis by ATP hydrolysis demonstrates intersite dependence (Q74233348)

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scientific article published on 01 August 2000

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English	Two transport binding sites of P-glycoprotein are unequal yet contingent: initial rate kinetic analysis by ATP hydrolysis demonstrates intersite dependence	scientific article published on 01 August 2000

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9 November 2019

Two transport binding sites of P-glycoprotein are unequal yet contingent: initial rate kinetic analysis by ATP hydrolysis demonstrates intersite dependence (English)

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9 November 2019

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E J Wang

1

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9 November 2019

C N Casciano

2

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9 November 2019

R P Clement

3

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9 November 2019

W W Johnson

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9 November 2019

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publication date

1 August 2000

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9 November 2019

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12

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Biochimica et Biophysica Acta

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1481

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9 November 2019

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9 November 2019

63-74

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9 November 2019

Multiple-drug resistance in human cancer

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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

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Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites.

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Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

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Identifiers

10.1016/S0167-4838(00)00125-4

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9 November 2019

1 reference

Europe PubMed Central

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9 November 2019

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