The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK (Q74272524)

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scientific article published on 01 October 2000

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English	The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK	scientific article published on 01 October 2000

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9 November 2019

The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK (English)

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9 November 2019

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S Z Abdel-Rahman

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R A El-Zein

2

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1 October 2000

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9 November 2019

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63-71

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9 November 2019

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9 November 2019

Metabolic activation and detoxification of tobacco-specific nitrosamines--a model for cancer prevention strategies

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Oxygen radicals potentiate the genetic toxicity of tobacco-specific nitrosamines

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Modulation of DNA repair by various inhibitors of DNA synthesis following 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced DNA damage

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Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen

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XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro

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XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage

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Identifiers

10.1016/S0304-3835(00)00532-2

1 reference

Europe PubMed Central

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9 November 2019

1 reference

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9 November 2019

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