titin (Q74314)

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largest known protein found in muscles of Homo sapiens
  • rhabdomyosarcoma antigen MU-RMS-40.14
  • connectin
  • TTN
  • Titin
edit
Language Label Description Also known as
English
titin
largest known protein found in muscles of Homo sapiens
  • rhabdomyosarcoma antigen MU-RMS-40.14
  • connectin
  • TTN
  • Titin

Statements

part of
chemical formula
C₁₆₉₇₂₃H₂₇₀₄₆₄N₄₅₆₈₈O₅₂₂₄₃S₉₁₂
0 references
molecular function
protein binding
determination method
IPI
38 references
retrieved
17 October 2017
stated in
Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.
GOA
curator
UniProt
UniProt protein ID
Q8WZ42
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
α-Synemin localizes to the M-band of the sarcomere through interaction with the M10 region of titin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
Molecular interactions with obscurin are involved in the localization of muscle-specific small ankyrin1 isoforms to subcompartments of the sarcoplasmic reticulum
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
Titin mutations as the molecular basis for dilated cardiomyopathy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-κB pathway in skeletal muscle
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
The interaction of titin and alpha-actinin is controlled by a phospholipid-regulated intramolecular pseudoligand mechanism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
The Muscle Ankyrin Repeat Proteins: CARP, ankrd2/Arpp and DARP as a Family of Titin Filament-based Stress Response Molecules
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
A calmodulin-binding sequence in the C-terminus of human cardiac titin kinase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.
GOA
curator
UniProt
UniProt protein ID
Q8WZ42
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-κB pathway in skeletal muscle
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
The interaction of titin and alpha-actinin is controlled by a phospholipid-regulated intramolecular pseudoligand mechanism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
Titin mutations as the molecular basis for dilated cardiomyopathy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
Molecular interactions with obscurin are involved in the localization of muscle-specific small ankyrin1 isoforms to subcompartments of the sarcoplasmic reticulum
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
α-Synemin localizes to the M-band of the sarcomere through interaction with the M10 region of titin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
A calmodulin-binding sequence in the C-terminus of human cardiac titin kinase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
The Muscle Ankyrin Repeat Proteins: CARP, ankrd2/Arpp and DARP as a Family of Titin Filament-based Stress Response Molecules
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
identical protein binding
determination method
IPI
6 references
retrieved
17 October 2017
stated in
Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
The Ig doublet Z1Z2: a model system for the hybrid analysis of conformational dynamics in Ig tandems from titin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
Structural basis for activation of the titin kinase domain during myofibrillogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
17 October 2017
stated in
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8WZ42&geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for activation of the titin kinase domain during myofibrillogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WZ42
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE TTN 208195 at fs.png
732 × 530; 8 KB
0 references
Commons category
Titin
0 references

Identifiers

RefSeq protein ID
Microsoft Academic ID
90671521
0 references
2910538737
0 references
PDB structure ID
WikiKids ID
Titine
0 references
 
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