Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1 (Q74454204)

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10 November 2019

title

Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1 (English)

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amyotrophic lateral sclerosis

10 November 2019

main subject

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J Kong

1

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10 November 2019

Z Xu

series ordinal

2

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10 November 2019

publication date

1 May 1998

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10 November 2019

published in

Journal of Neuroscience

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10 November 2019

volume

18

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10 November 2019

page(s)

3241-3250

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10 November 2019

issue

9

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Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease

10 November 2019

cites work

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12 December 2020

Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis

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12 December 2020

Familial adult motor neuron disease: amyotrophic lateral sclerosis

1 reference

12 December 2020

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions

1 reference

12 December 2020

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

12 December 2020

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

1 reference

12 December 2020

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide

1 reference

12 December 2020

Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice

1 reference

12 December 2020

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Prognosis in familial amyotrophic lateral sclerosis: progression and survival in patients with glu100gly and ala4val mutations in Cu,Zn superoxide dismutase

1 reference

12 December 2020

Mitochondria, free radicals, and neurodegeneration

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12 December 2020

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

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12 December 2020

Cytopathology of amyotrophic lateral sclerosis

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12 December 2020

Expression of a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis induces mitochondrial alteration and increase of cytosolic Ca2+ concentration in transfected neuroblastoma SH-SY5Y cells

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12 December 2020

The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease

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12 December 2020

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1 reference

12 December 2020

Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease

1 reference

12 December 2020

Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: neurochemical correlates of selective vulnerability

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12 December 2020

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

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12 December 2020

ALS, SOD and peroxynitrite

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12 December 2020

10.1523/JNEUROSCI.18-09-03241.1998

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9547233%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

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10 November 2019

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