Identification of the first Rho-GEF inhibitor, TRIPalpha, which targets the RhoA-specific GEF domain of Trio (Q74477524)

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11 November 2019

title

Identification of the first Rho-GEF inhibitor, TRIPalpha, which targets the RhoA-specific GEF domain of Trio (English)

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11 November 2019

author name string

Susanne Schmidt

1

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11 November 2019

Sylvie Diriong

2

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11 November 2019

Jean Méry

3

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11 November 2019

Eric Fabbrizio

4

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11 November 2019

Anne Debant

5

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11 November 2019

publication date

1 July 2002

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11 November 2019

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11 November 2019

volume

523

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11 November 2019

issue

1-3

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11 November 2019

page(s)

35-42

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Rho GTPases and the actin cytoskeleton

11 November 2019

cites work

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Proteins regulating Ras and its relatives

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Signal-dependent membrane targeting by pleckstrin homology (PH) domains

7 January 2021

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The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains

7 January 2021

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The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo

7 January 2021

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The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin

7 January 2021

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UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.

7 January 2021

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The guanine nucleotide exchange factor trio mediates axonal development in the Drosophila embryo

7 January 2021

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Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding

7 January 2021

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Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila

7 January 2021

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The Drosophila trio plays an essential role in patterning of axons by regulating their directional extension.

7 January 2021

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Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos

7 January 2021

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The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth

7 January 2021

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Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2.

7 January 2021

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Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

7 January 2021

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Design and synthesis of a peptide derived from positions 195-244 of human cdc25C phosphatase

7 January 2021

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Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42

7 January 2021

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Interactions among proteins involved in bud-site selection and bud-site assembly in Saccharomyces cerevisiae

7 January 2021

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

7 January 2021

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Selection of genetic agents from random peptide aptamer expression libraries

7 January 2021

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Inhibition of mammalian cell proliferation by genetically selected peptide aptamers that functionally antagonize E2F activity

7 January 2021

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Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein

7 January 2021

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Peptide aptamers targeting the hepatitis B virus core protein: a new class of molecules with antiviral activity

7 January 2021

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Rho GTPases in neuronal morphogenesis

7 January 2021

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Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid

7 January 2021

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Small GTPase RhoG is a key regulator for neurite outgrowth in PC12 cells

7 January 2021

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Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain

7 January 2021

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10.1016/S0014-5793(02)02928-9

7 January 2021

Identifiers

DOI

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11 November 2019

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