Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor (Q74509439)

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11 November 2019

title

Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor (English)

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11 November 2019

3

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11 November 2019

Peter J. Ratcliffe

8

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11 November 2019

author name string

E C Vaux

1

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11 November 2019

S M Wood

2

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11 November 2019

L G Nicholls

4

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11 November 2019

K M Yeates

5

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11 November 2019

C W Pugh

6

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11 November 2019

P H Maxwell

7

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11 November 2019

language of work or name

English

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publication date

12 September 2001

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Journal of Biological Chemistry

11 November 2019

published in

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11 November 2019

volume

276

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11 November 2019

issue

47

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11 November 2019

page(s)

44323-44330

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

11 November 2019

cites work

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Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

21 January 2018

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Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

21 January 2018

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

21 January 2018

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

21 January 2018

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Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

21 January 2018

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Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

21 January 2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

21 January 2018

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

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Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

21 January 2018

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

21 January 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

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Mutations of the VHL tumour suppressor gene in renal carcinoma

21 January 2018

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

21 January 2018

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Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

21 January 2018

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Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

21 January 2018

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Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

21 January 2018

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p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

21 January 2018

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EPAS1 trans-activation during hypoxia requires p42/p44 MAPK

21 January 2018

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Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression

21 January 2018

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Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

21 January 2018

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Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism

21 January 2018

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Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

21 January 2018

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Isolation and characterization of Chinese hamster ovary cell mutants defective in glucose transport

21 January 2018

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Comparative sequence analysis of the VHL tumor suppressor gene

21 January 2018

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High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons

21 January 2018

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HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation

21 January 2018

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Mutational spectrum of ICR-191 at the hprt locus in human lymphoblastoid cells

21 January 2018

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Discovery of AT gene sparks biomedical research bonanza

21 January 2018

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Tumour suppression by the human von Hippel-Lindau gene product

21 January 2018

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The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

21 January 2018

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The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

21 January 2018

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Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells

21 January 2018

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The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis

21 January 2018

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A single ataxia telangiectasia gene with a product similar to PI-3 kinase

21 January 2018

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24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.7792600

Identifiers

DOI

10.1074/JBC.M104678200

1 reference

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11 November 2019

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