Role of human liver P450s and cytochrome b5 in the reductive metabolism of 3'-azido-3'-deoxythymidine (AZT) to 3'-amino-3'-deoxythymidine (Q74546234)

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11 November 2019

title

Role of human liver P450s and cytochrome b5 in the reductive metabolism of 3'-azido-3'-deoxythymidine (AZT) to 3'-amino-3'-deoxythymidine (English)

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11 November 2019

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X R Pan-Zhou

1

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11 November 2019

E Cretton-Scott

2

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11 November 2019

X J Zhou

3

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11 November 2019

M X Yang

4

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11 November 2019

J M Lasker

5

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11 November 2019

J P Sommadossi

6

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11 November 2019

language of work or name

English

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publication date

1 March 1998

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11 November 2019

published in

Biochemical Pharmacology

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11 November 2019

volume

55

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11 November 2019

issue

6

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11 November 2019

page(s)

757-766

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Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

11 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Zidovudine-associated myopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Mitochondrial myopathy caused by long-term zidovudine therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

DNA Polymerases versus HIV Reverse Transcriptase in AIDS Therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Inhibition of mammalian DNA polymerase-associated 3' to 5' exonuclease activity by 5'-monophosphates of 3'-azido-3'-deoxythymidine and 3'-amino-3'-deoxythymidine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

AZT causes tissue-specific inhibition of mitochondrial bioenergetic function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Cytochrome c oxidase reaction improves histopathological assessment of zidovudine myopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Zidovudine myopathy: a distinctive disorder associated with mitochondrial dysfunction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Clinical pharmacokinetics of 3'-azido-3'-deoxythymidine (zidovudine) and catabolites with formation of a toxic catabolite, 3'-amino-3'-deoxythymidine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Quantification of 3'-amino-3'-deoxythymidine, a toxic catabolite of 3'-azido-3'-deoxythymidine (zidovudine) in human plasma by high-performance liquid chromatography using precolumn derivatization with fluorescamine and fluorescence detection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Reduction of 3'-azido-3'-deoxythymidine to 3'-amino-3'-deoxythymidine in human liver microsomes and its relationship to cytochrome P450

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Reversal of the cytotoxicity of 3'-amino-3'-deoxythymidine by pyrimidine deoxyribonucleosides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Thiol reduction of 3'-azidothymidine to 3'-aminothymidine: kinetics and biomedical implications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

A continuous spectrophotometric determination of hepatic microsomal azo reductase activity and its dependence on cytochrome P-450.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-l,2,4-benzotriazine-l ,4-dioxide (SR 4233, WIN 59075) by mouse liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

One-electron reductive bioactivation of 2,3,5,6-tetramethylbenzoquinone by cytochrome P450

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Isolation of P450 enzymes from human liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

In vitro methods for assessing human hepatic drug metabolism: their use in drug development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

Selective inhibition of major drug metabolizing cytochrome P450 isozymes in human liver microsomes by carbon monoxide.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900538-8

10.1016/S0006-2952(97)00538-8

7 January 2021

Identifiers

DOI

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11 November 2019

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