Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone (Q74546253)

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11 November 2019

title

Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone (English)

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11 November 2019

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3

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11 November 2019

author name string

T P Reilly

series ordinal

1

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11 November 2019

F H Bellevue

series ordinal

2

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11 November 2019

C K Svensson

series ordinal

4

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11 November 2019

language of work or name

English

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publication date

1 March 1998

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11 November 2019

published in

Biochemical Pharmacology

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11 November 2019

volume

55

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11 November 2019

issue

6

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11 November 2019

page(s)

803-810

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Trimethoprim-sulphamethoxazole appears more effective than aerosolized pentamidine as secondary prophylaxis against Pneumocystis carinii pneumonia in patients with AIDS.

11 November 2019

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Adverse Reactions to Trimethoprim-Sulfamethoxazole in Patients with the Acquired Immunodeficiency Syndrome

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Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A controlled trial of trimethoprim-sulfamethoxazole versus trimethoprim-dapsone

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Pneumocystis carinii Pneumonia: A Comparison Between Patients with the Acquired Immunodeficiency Syndrome and Patients with Other Immunodeficiencies

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Bioactivation and bioinactivation of drugs and drug metabolites: Relevance to adverse drug reactions

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7 January 2021

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Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity

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Prominence of slow acetylator phenotype among patients with sulfonamide hypersensitivity reactions

7 January 2021

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Acetylation phenotype and cutaneous hypersensitivity to trimethoprim-sulphamethoxazole in HIV-infected patients

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Sulfamethoxazole is metabolized to the hydroxylamine in humans

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Diagnosis of sulfonamide hypersensitivity reactions by in-vitro "rechallenge" with hydroxylamine metabolites

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In vitro cytotoxicity as a marker of hypersensitivity to sulphamethoxazole in patients with HIV.

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Time-course of toxicity of reactive sulfonamide metabolites

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Dapsone, trimethoprim, and sulfamethoxazole plasma levels during treatment of Pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome (AIDS). Evidence of drug interactions

7 January 2021

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Clinical pharmacokinetics of dapsone

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Agranulocytosis associated with malaria prophylaxis with Maloprim.

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The use of cimetidine as a selective inhibitor of dapsone N-hydroxylation in man.

7 January 2021

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Formation and elimination of sulphamethoxazole hydroxylamine after oral administration of sulphamethoxazole

7 January 2021

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Adverse reactions to dapsone in persons infected with human immunodeficiency virus

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Dapsone-induced hematologic toxicity: comparison of the methemoglobin-forming ability of hydroxylamine metabolites of dapsone in rat and human blood

7 January 2021

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Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes

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Bioactivation of dapsone to a cytotoxic metabolite: in vitro use of a novel two compartment system which contains human tissues

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An investigation of the role of metabolism in dapsone-induced methaemoglobinaemia using a two compartment in vitro test system

7 January 2021

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

7 January 2021

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Applications of the MTT assay to functional studies of mouse intestinal intraepithelial lymphocytes

7 January 2021

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The use of a three compartment in vitro model to investigate the role of hepatic drug metabolism in drug-induced blood dyscrasias

7 January 2021

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A rapid in vitro assay for evaluation of metabolism-dependent cytotoxicity of antiepileptic drugs on isolated human lymphocytes

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Cellular toxicity of sulfamethoxazole reactive metabolites--I. Inhibition of intracellular esterase activity prior to cell death

7 January 2021

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Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro

7 January 2021

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Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro--II. Movement of dapsone across a semipermeable membrane into erythrocytes and plasma

7 January 2021

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Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro. IV: Implications for the development of agranulocytosis

7 January 2021

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10.1016/S0006-2952(97)00547-9

7 January 2021

Identifiers

DOI

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11 November 2019

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