Genetic polymorphism of drug metabolizing enzymes: new mutations in CYP2D6 and CYP2A6 genes in Japanese (Q74549948)

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11 November 2019

review article

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title

Genetic polymorphism of drug metabolizing enzymes: new mutations in CYP2D6 and CYP2A6 genes in Japanese (English)

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11 November 2019

author name string

T Yokoi

series ordinal

1

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11 November 2019

T Kamataki

series ordinal

2

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11 November 2019

publication date

1 April 1998

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11 November 2019

published in

Pharmaceutical Research

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11 November 2019

volume

15

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11 November 2019

issue

4

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11 November 2019

page(s)

517-524

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Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

11 November 2019

cites work

1 reference

12 December 2020

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1 reference

12 December 2020

Nicotine-derived N-nitrosamines and tobacco-related cancer: current status and future directions

1 reference

12 December 2020

Genetic and metabolic criteria for the assignment of debrisoquine 4-hydroxylation (cytochrome P4502D6) phenotypes

1 reference

12 December 2020

Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

1 reference

12 December 2020

Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1

1 reference

12 December 2020

Biological effects of the new platelet-activating factor receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride.

1 reference

12 December 2020

Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype

1 reference

12 December 2020

Poor metabolisers of nicotine and CYP2D6 polymorphism

1 reference

12 December 2020

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

1 reference

12 December 2020

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

1 reference

12 December 2020

Nomenclature for human CYP2D6 alleles.

1 reference

12 December 2020

The CYP2 A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis

1 reference

12 December 2020

Deficient C-oxidation of nicotine

1 reference

12 December 2020

Formation of morphine from codeine in Chinese subjects of different CYP2D6 genotypes

1 reference

12 December 2020

A new CYP2D6 allele with a nine base insertion in exon 9 in a Japanese population associated with poor metabolizer phenotype

1 reference

12 December 2020

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

1 reference

12 December 2020

The influence of enzyme induction on polymorphic sparteine oxidation

1 reference

12 December 2020

Determination of dextromethorphan metabolic phenotype by salivary analysis with a reference to genotype in Chinese patients receiving renal hemodialysis

1 reference

12 December 2020

Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of human cytochrome P450 CYP2D6 gene

1 reference

12 December 2020

Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine

1 reference

12 December 2020

Propranolol disposition in Chinese subjects of different CYP2D6 genotypes

1 reference

12 December 2020

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles

1 reference

12 December 2020

Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations

1 reference

12 December 2020

Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture

1 reference

12 December 2020

The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds.

1 reference

12 December 2020

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population

1 reference

12 December 2020

(+)-cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes

1 reference

12 December 2020

Human cytochrome P450IIA3: cDNA sequence, role of the enzyme in the metabolic activation of promutagens, comparison to nitrosamine activation by human cytochrome P450IIE1.

1 reference

12 December 2020

Differential inhibition of coumarin 7-hydroxylase activity in mouse and human liver microsomes

1 reference

12 December 2020

Evidence for polymorphic oxidation of sparteine in Japanese subjects

1 reference

12 December 2020

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

1 reference

12 December 2020

A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502).

1 reference

12 December 2020

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

1 reference

12 December 2020

Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese

1 reference

12 December 2020

Recent studies of nicotine metabolism in humans

1 reference

12 December 2020

A multifamily study on the relationship between CYP2C19 genotype and S-mephenytoin oxidation phenotype

1 reference

12 December 2020

Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.

1 reference

12 December 2020

Concordance of P450 2D6 (debrisoquine hydroxylase) phenotype and genotype: inability of dextromethorphan metabolic ratio to discriminate reliably heterozygous and homozygous extensive metabolizers

1 reference

12 December 2020

S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride by rat hepatic flavin-containing monooxygenase 1 expressed in yeast

1 reference

12 December 2020

Interindividual variability of coumarin 7-hydroxylation in healthy volunteers

1 reference

12 December 2020

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1 reference

12 December 2020

Interindividual variation of beta-adrenoceptor blocking drugs, plasma concentration and effect: influence of genetic status on behaviour of atenolol, bopindolol and metoprolol

1 reference

12 December 2020

CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes

1 reference

12 December 2020

Characterization of the human cytochrome P4502D6 promoter. A potential role for antagonistic interactions between members of the nuclear receptor family

1 reference

12 December 2020

The cytochrome P450 CYP2D6 allelic variant CYP2D6J and related polymorphisms in a European population

1 reference

12 December 2020

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

1 reference

12 December 2020

Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse

1 reference

12 December 2020

Purification and characterization of human liver microsomal cytochrome P-450 2A6

1 reference

12 December 2020

Molecular basis of polymorphic drug metabolism

1 reference

12 December 2020

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene

1 reference

12 December 2020

Metabolism of nicotine

1 reference

12 December 2020

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism

1 reference

12 December 2020

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese

1 reference

12 December 2020

High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans

1 reference

12 December 2020

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

1 reference

12 December 2020

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans

1 reference

12 December 2020

Metoprolol oxidation polymorphism in a Korean population: comparison with native Japanese and Chinese populations

1 reference

12 December 2020

Role of human cytochrome P4502A6 in C-oxidation of nicotine

1 reference

12 December 2020

Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes

1 reference

12 December 2020

A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1011913407147

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9587945%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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