Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): comparison with other delivery routes (Q74549978)

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11 November 2019

title

Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): comparison with other delivery routes (English)

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11 November 2019

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P L Nicklin

1

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11 November 2019

D Bayley

2

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11 November 2019

J Giddings

3

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11 November 2019

S J Craig

4

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11 November 2019

L L Cummins

5

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J G Hastewell

6

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J A Phillips

7

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11 November 2019

publication date

1 April 1998

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11 November 2019

published in

Pharmaceutical Research

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11 November 2019

volume

15

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issue

4

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page(s)

583-591

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Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

11 November 2019

cites work

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12 December 2020

Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice

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12 December 2020

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

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12 December 2020

The transport of acidic amino acids and their analogues across monolayers of human intestinal absorptive (Caco-2) cells in vitro

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12 December 2020

Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo

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12 December 2020

In vivo studies with phosphorothioate oligonucleotides: pharmacokinetics prologue

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12 December 2020

Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey

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12 December 2020

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

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12 December 2020

Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats.

1 reference

12 December 2020

Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression

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12 December 2020

Quantitation of phosphorothioate oligonucleotides in human plasma

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12 December 2020

Pharmacokinetic properties of several novel oligonucleotide analogs in mice

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12 December 2020

Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate

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12 December 2020

Tritium labeling of antisense oligonucleotides by exchange with tritiated water

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12 December 2020

Clearance kinetics, biodistribution, and organ saturability of phosphorothioate oligodeoxynucleotides in mice

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12 December 2020

Interactions of phosphodiester and phosphorothioate oligonucleotides with intestinal epithelial Caco-2 cells.

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12 December 2020

Organ distribution and stability of phosphorothioated oligodeoxyribonucleotides in mice

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12 December 2020

Antisense oligonucleotides as antiviral agents

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12 December 2020

Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression

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12 December 2020

In vivo stability, disposition and metabolism of a "hybrid" oligonucleotide phosphorothioate in rats

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12 December 2020

Pharmacokinetics and tissue distribution in rats of an oligodeoxynucleotide phosphorothioate (GEM 91) developed as a therapeutic agent for human immunodeficiency virus type-1.

1 reference

12 December 2020

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

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12 December 2020

Pharmacokinetics, metabolism, and elimination of a 20-mer phosphorothioate oligodeoxynucleotide (CGP 69846A) after intravenous and subcutaneous administration

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12 December 2020

Pharmacokinetics of antisense oligonucleotides

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12 December 2020

DNA antisense therapy for asthma in an animal model

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12 December 2020

Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration

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12 December 2020

Identifiers

DOI

10.1023/A:1011934011690

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11 November 2019

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