Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein (Q74599349)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11590151%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

title

Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11590151%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference

R Bussell

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11590151%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

D Eliezer

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11590151%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

language of work or name

English

0 references

publication date

4 October 2001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11590151%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

11 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11590151%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

volume

276

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11590151%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

issue

49

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11590151%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

page(s)

45996-46003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11590151%20AND%20SRC:MED&resulttype=core&format=json

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

11 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Involvement of alpha-synuclein in Parkinson's disease and other neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

A Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Parkinson's disease and other alpha-synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

NMR structural and dynamic characterization of the acid-unfolded state of apomyoglobin provides insights into the early events in protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Non-A beta component of Alzheimer's disease amyloid (NAC) is amyloidogenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

NMR View: A computer program for the visualization and analysis of NMR data

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Chemical shifts as a tool for structure determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Mapping of the spectral densities of N-H bond motions in eglin c using heteronuclear relaxation experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Spectral density function mapping using 15N relaxation data exclusively

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Internal mobility in the partially folded DNA binding and dimerization domains of GAL4: NMR analysis of the N-H spectral density functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Protein Backbone Dynamics and 15 N Chemical Shift Anisotropy from Quantitative Measurement of Relaxation Interference Effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Native and non-native secondary structure and dynamics in the pH 4 intermediate of apomyoglobin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Structural and dynamic characterization of partially folded states of apomyoglobin and implications for protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Empirical Predictions of Protein Conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Synucleins are a novel class of substrates for G protein-coupled receptor kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106777200

21 January 2018

Identifiers

DOI

10.1074/JBC.M106777200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11590151%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference