Sphingosine kinase 1 (Q7576799)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NYA1

NAD kinase/diacylglycerol kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NYA1

Diacylglycerol kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

sphingosine-1-phosphate receptor activity

1 reference

9 May 2019

Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

1 reference

9 May 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

1 reference

9 May 2019

DNA binding

1 reference

9 May 2019

The nucleotide-binding site of human sphingosine kinase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

calmodulin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

3 references

9 May 2019

9 May 2019

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

The nucleotide-binding site of human sphingosine kinase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

protein binding

7 references

9 May 2019

Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

protein phosphatase 2A binding

1 reference

9 May 2019

A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

sphinganine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYA1&geneProductId=UniProtKB:Q9NYA1

4 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYA1&geneProductId=UniProtKB:Q9NYA1

7 November 2018

7 November 2018

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYA1&geneProductId=UniProtKB:Q9NYA1

7 November 2018

The nucleotide-binding site of human sphingosine kinase 1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYA1&geneProductId=UniProtKB:Q9NYA1

D-erythro-sphingosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

3 references

1 January 2018

1 January 2018

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

1 January 2018

Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

NAD+ kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

1 reference

9 May 2019

magnesium ion binding

1 reference

9 May 2019

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

sphinganine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

6 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Coupling between endocytosis and sphingosine kinase 1 recruitment.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

The nucleotide-binding site of human sphingosine kinase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

lipid binding

1 reference

9 May 2019

Coupling between endocytosis and sphingosine kinase 1 recruitment.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

D-erythro-sphingosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

5 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

5 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

1 reference

9 May 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

4 references

9 May 2019

9 May 2019

Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

9 May 2019

A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

1 reference

1 January 2018

cytosol

Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

nucleus

ISS

clathrin-coated pit

1 reference

8 April 2019

Coupling between endocytosis and sphingosine kinase 1 recruitment.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

early endosome membrane

1 reference

9 May 2019

Coupling between endocytosis and sphingosine kinase 1 recruitment.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

1 reference

9 May 2019

endosome membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

1 reference

9 May 2019

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

1 reference

9 May 2019

synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

1 reference

9 May 2019

intracellular signal transduction

biological process

1 reference

9 May 2019

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

positive regulation of fibroblast proliferation

1 reference

9 May 2019

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

regulation of tumor necrosis factor-mediated signaling pathway

1 reference

9 May 2019

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

sphingosine biosynthetic process

IGI

positive regulation of mitotic cell cycle

1 reference

9 May 2019

Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

sphingolipid biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

1 reference

9 May 2019

positive regulation of angiogenesis

1 reference

9 May 2019

Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

positive regulation of cell growth

1 reference

9 May 2019

Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

brain development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

blood vessel development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

positive regulation of NF-kappaB transcription factor activity

1 reference

1 January 2018

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

positive regulation of peptidyl-threonine phosphorylation

1 reference

9 May 2019

Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

protein folding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

1 reference

9 May 2019

positive regulation of cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

regulation of interleukin-1 beta production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

inflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

sphingoid catabolic process

NAS

1 reference

9 May 2019

Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

positive regulation of protein ubiquitination

NAS

1 reference

9 May 2019

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

positive regulation of smooth muscle contraction

1 reference

9 May 2019

Sphingosine kinase modulates microvascular tone and myogenic responses through activation of RhoA/Rho kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

calcium-mediated signaling

1 reference

9 May 2019

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

signal transduction

1 reference

9 May 2019

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

sphingosine-1-phosphate receptor signaling pathway

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

lipid phosphorylation

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

positive regulation of cell migration

1 reference

9 May 2019

Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

negative regulation of apoptotic process

metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NYA1&geneProductId=UniProtKB:Q9NYA1

1 reference

27 March 2018

positive regulation of NIK/NF-kappaB signaling

1 reference

9 May 2019

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

positive regulation of mitotic nuclear division

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

cellular response to hydrogen peroxide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

DNA biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

sphingolipid mediated signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

regulation of endocytosis

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Coupling between endocytosis and sphingosine kinase 1 recruitment.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

positive regulation of interleukin-17 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

1 reference

9 May 2019

response to tumor necrosis factor

ISS

1 reference

9 May 2019

Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor κB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

negative regulation of apoptotic process

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

9 May 2019

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

positive regulation of p38MAPK cascade

1 reference

9 May 2019

Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor κB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NYA1

Diacylglycerol kinase, catalytic domain

Gene Atlas image

PBB GE SPHK1 219257 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NYA1

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016