Suppressor of cytokine signaling 1 (Q7644656)

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mammalian protein found in Homo sapiens

JAB
JAK binding protein
SOCS1
STAT induced SH3 protein 1
suppressor of cytokine signaling 1
TIP-3
Tec-interacting protein 3
STAT-induced STAT inhibitor 1
SSI-1
JAK-binding protein
cytokine-inducible SH2 protein 1

Language	Label	Description	Also known as
English	Suppressor of cytokine signaling 1	mammalian protein found in Homo sapiens	JAB JAK binding protein SOCS1 STAT induced SH3 protein 1 suppressor of cytokine signaling 1 TIP-3 Tec-interacting protein 3 STAT-induced STAT inhibitor 1 SSI-1 JAK-binding protein cytokine-inducible SH2 protein 1

Statements

1 reference

13 November 2019

UniProt protein ID

suppressor of cytokine signalling 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15524

SOCS box-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15524

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15524

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SOCS box domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SOCS1, SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

insulin-like growth factor receptor binding

determination method

1 reference

8 April 2019

Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

protein kinase inhibitor activity

determination method

1 reference

8 April 2019

A family of cytokine-inducible inhibitors of signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

protein binding

determination method

5 references

8 April 2019

COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

8 April 2019

COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

8 April 2019

The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

8 April 2019

A quantitative protein interaction network for the ErbB receptors using protein microarrays

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

8 April 2019

SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

protein kinase binding

determination method

1 reference

8 April 2019

Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

kinase inhibitor activity

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15524&geneProductId=UniProtKB:O15524

determination method

1-phosphatidylinositol-3-kinase regulator activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

cytoplasmic ribonucleoprotein granule

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

phosphatidylinositol 3-kinase complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

biological process

intracellular signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

protein ubiquitination

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

regulation of growth

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

negative regulation of signal transduction

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

negative regulation of protein kinase activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

negative regulation of receptor signaling pathway via JAK-STAT

determination method

5 references

8 April 2019

Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

8 April 2019

MiR-221 accentuates IFN׳s anti-HCV effect by downregulating SOCS1 and SOCS3

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

positive regulation of regulatory T cell differentiation

determination method

1 reference

8 April 2019

Downregulation of inflammatory microRNAs by Ig-like transcript 3 is essential for the differentiation of human CD8(+) T suppressor cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

interleukin-7-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

regulation of protein phosphorylation

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15524&geneProductId=UniProtKB:O15524

determination method

cytokine-mediated signaling pathway

determination method

positive regulation of CD4-positive, alpha-beta T cell differentiation

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15524&geneProductId=UniProtKB:O15524

determination method

negative regulation of CD8-positive, alpha-beta T cell differentiation

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15524&geneProductId=UniProtKB:O15524

determination method

receptor signaling pathway via JAK-STAT

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

regulation of activation of Janus kinase activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

cytokine-mediated signaling pathway

determination method

negative regulation of kinase activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

regulation of tyrosine phosphorylation of STAT protein

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

negative regulation of tyrosine phosphorylation of STAT protein

determination method

3 references

regulation of phosphatidylinositol 3-kinase activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

fat cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

regulation of receptor signaling pathway via JAK-STAT

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

negative regulation of insulin receptor signaling pathway

determination method

3 references

phosphatidylinositol phosphate biosynthetic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

cellular response to amino acid stimulus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15524

determination method

Gene Atlas image

PBB GE SOCS1 210001 s at fs.png
732 × 530; 11 KB

0 references

SOCS box domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15524

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15524

SOCS1, SH2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15524

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000329418

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000329418

ENSP00000496577

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496577

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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