Transient receptor potential cation channel subfamily C member 1 (Q7671460)

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mammalian protein found in Homo sapiens

capacitative calcium channel protein Trp1
transient receptor protein 1
TRPC1
TRP-1
short transient receptor potential channel 1
transient receptor potential canonical 1

Language	Label	Description	Also known as
English	Transient receptor potential cation channel subfamily C member 1	mammalian protein found in Homo sapiens	capacitative calcium channel protein Trp1 transient receptor protein 1 TRPC1 TRP-1 short transient receptor potential channel 1 transient receptor potential canonical 1

Statements

1 reference

13 November 2019

UniProt protein ID

Transient receptor potential channel, canonical 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48995

Ankyrin repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48995

transient receptor potential channel

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Ion transport domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat-containing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

store-operated calcium channel activity

determination method

1 reference

16 July 2018

Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48995&geneProductId=UniProtKB:P48995

determination method

transmembrane transporter binding

determination method

1 reference

1 January 2018

Specific association of the gene product of PKD2 with the TRPC1 channel

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48995&geneProductId=UniProtKB:P48995

determination method

calcium channel activity

determination method

inositol 1,4,5 trisphosphate binding

determination method

1 reference

16 July 2018

Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48995&geneProductId=UniProtKB:P48995

determination method

ion channel activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

protein binding

determination method

5 references

8 April 2019

Specific association of the gene product of PKD2 with the TRPC1 channel

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

8 April 2019

Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

8 April 2019

Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

8 April 2019

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

8 April 2019

Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

cation channel activity

determination method

1 reference

8 April 2019

STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

determination method

2 references

receptor complex

determination method

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

plasma membrane

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

8 April 2019

Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

8 April 2019

Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

integral component of plasma membrane

determination method

1 reference

16 July 2018

TRPC1, a human homolog of a Drosophila store-operated channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48995&geneProductId=UniProtKB:P48995

determination method

cation channel complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

biological process

melanin biosynthetic process

determination method

1 reference

8 April 2019

Contribution of melanogenic proteins to the heterogeneous pigmentation of human melanocytes

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

regulation of cardiac conduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

regulation of cytosolic calcium ion concentration

determination method

1 reference

16 July 2018

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48995&geneProductId=UniProtKB:P48995

determination method

positive regulation of release of sequestered calcium ion into cytosol

determination method

1 reference

8 April 2019

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

calcium ion transmembrane transport

determination method

manganese ion transport

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

transmembrane transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

regulation of cytosolic calcium ion concentration

determination method

calcium ion transmembrane transport

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48995

determination method

physically interacts with

2-aminoethoxydiphenylborate

channel blocker

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

Gene Atlas image

PBB GE TRPC1 205803 s at fs.png
732 × 530; 11 KB

0 references

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000481537

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000481537

ENSP00000273482

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000273482

ENSP00000419313

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419313

ENSP00000418708

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418708

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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