Tachykinin receptor 1 (Q7673856)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25103

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25103&geneProductId=UniProtKB:P25103

1 reference

31 October 2017

protein binding

3 references

8 April 2019

Characterization of the endokinins: Human tachykinins with cardiovascular activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

8 April 2019

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

8 April 2019

Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

substance P receptor activity

Characterization of the endokinins: Human tachykinins with cardiovascular activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

tachykinin receptor activity

Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel tachykinin receptor antagonists

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25103&geneProductId=UniProtKB:P25103

6 references

5 June 2018

5 June 2018

Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25103&geneProductId=UniProtKB:P25103

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25103&geneProductId=UniProtKB:P25103

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25103&geneProductId=UniProtKB:P25103

5 June 2018

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25103&geneProductId=UniProtKB:P25103

5 June 2018

Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25103&geneProductId=UniProtKB:P25103

integral component of plasma membrane

1 reference

8 April 2019

Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

cell periphery

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

cell surface

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

dendrite

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

cell body

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

sperm flagellum

1 reference

8 April 2019

A role for tachykinins in the regulation of human sperm motility.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

sperm head

1 reference

8 April 2019

A role for tachykinins in the regulation of human sperm motility.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

sperm midpiece

1 reference

5 June 2018

A role for tachykinins in the regulation of human sperm motility.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25103&geneProductId=UniProtKB:P25103

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

7 references

8 April 2019

8 April 2019

Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

8 April 2019

Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

regulation of uterine smooth muscle contraction

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

phospholipase C-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

response to pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

detection of abiotic stimulus

1 reference

8 April 2019

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

inflammatory response

1 reference

8 April 2019

Substance P induces tumor necrosis factor-alpha release from human skin via mitogen-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of smooth muscle contraction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25103&geneProductId=UniProtKB:P25103

1 reference

5 June 2018

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

1 reference

8 April 2019

chemical synaptic transmission

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25103&geneProductId=UniProtKB:P25103

1 reference

5 June 2018

aggressive behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

acute inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of leukocyte migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

angiotensin-mediated drinking behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

learning or memory

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

long-term memory

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

regulation of blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

associative learning

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

response to heat

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

response to hormone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

response to ozone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of epithelial cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

response to auditory stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

regulation of smooth muscle cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

sensory perception of pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of synaptic transmission, cholinergic

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of synaptic transmission, GABAergic

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

response to estradiol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

response to progesterone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

response to nicotine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

operant conditioning

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of renal sodium excretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

ejaculation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

eating behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of vascular permeability

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

response to morphine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of action potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of ossification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of vasoconstriction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of saliva secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of hormone secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

behavioral response to pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

regulation of smooth muscle cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of lymphocyte proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of epithelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of stress fiber assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

response to electrical stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

smooth muscle contraction involved in micturition

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of uterine smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

tachykinin receptor signaling pathway

Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel tachykinin receptor antagonists

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

8 April 2019

Characterization of the endokinins: Human tachykinins with cardiovascular activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

IMP

8 April 2019

Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

positive regulation of flagellated sperm motility

IMP

1 reference

5 June 2018

A role for tachykinins in the regulation of human sperm motility.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25103&geneProductId=UniProtKB:P25103

G protein-coupled receptor signaling pathway

IMP

positive regulation of cytosolic calcium ion concentration

1 reference

1 January 2018

Characterization of the endokinins: Human tachykinins with cardiovascular activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25103

physically interacts with

1 reference

2086

17 August 2016

1 reference

2088

English

H-DL-Pyr-DL-Ala-DL-Asp-DL-Pro-DL-Asn-DL-Lys-DL-Phe-DL-Tyr-Gly-DL-Leu-DL-Met-NH2

17 August 2016

has use

agonist

1 reference

2094

17 August 2016

1 reference

2098

17 August 2016

1 reference

3490

17 August 2016

1 reference

5751

17 August 2016

1 reference

7623

17 August 2016

1 reference

3510

17 August 2016

1 reference

5742

17 August 2016

1 reference

2110

17 August 2016

1 reference

2111

17 August 2016

1 reference

5757

17 August 2016

1 reference

5752

English

17 August 2016

vestipitant

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL522987

ezlopitant

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL515966

tradipitant

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3544984

netupitant

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL206253

vofopitant

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL522302

serlopitant

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL447955

Gene Atlas image

PBB GE TACR1 208049 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25103

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

28 October 2013

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016