Teratocarcinoma-derived growth factor 1 (Q7701617)

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mammalian protein found in Homo sapiens

• cripto-1 growth factor
• CRGF
• epidermal growth factor-like cripto protein CR1
• teratocarcinoma-derived growth factor 1
• TDGF1

edit

Language	Label	Description	Also known as
English	Teratocarcinoma-derived growth factor 1	mammalian protein found in Homo sapiens	cripto-1 growth factor CRGF epidermal growth factor-like cripto protein CR1 teratocarcinoma-derived growth factor 1 TDGF1

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P13385

part of

Teratocarcinoma-derived growth factor Cripto

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P13385

Cryptic/Cripto, CFC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P13385

encoded by

TDGF1

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P13385

molecular function

protein binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IPI

growth factor activity

determination method or standard

IDA

IEA

4 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IEA

retrieved

8 April 2019

stated in

Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

retrieved

8 April 2019

stated in

Identification and biological characterization of an epidermal growth factor-related protein: cripto-1

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

signaling receptor binding

determination method or standard

IDA

1 reference

retrieved

31 January 2018

stated in

Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13385&geneProductId=UniProtKB:P13385

determination method or standard

IDA

signaling receptor binding

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IBA

nodal binding

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IBA

activin receptor binding

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IBA

cell component

membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IEA

plasma membrane

determination method or standard

TAS

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IEA

cell surface

determination method or standard

IDA

1 reference

retrieved

31 January 2018

stated in

Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13385&geneProductId=UniProtKB:P13385

determination method or standard

IDA

apical plasma membrane

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

membrane raft

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

anchored component of membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IEA

extrinsic component of plasma membrane

determination method or standard

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

ISS

extracellular space

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

extracellular region

determination method or standard

IEA

1 reference

retrieved

31 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13385&geneProductId=UniProtKB:P13385

determination method or standard

IEA

extracellular region

determination method or standard

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IBA

cell surface

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IBA

biological process

cell differentiation

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Cripto: a tumor growth factor and more

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

TAS

cellular response to interleukin-6

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

epidermal growth factor receptor signaling pathway

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Identification and biological characterization of an epidermal growth factor-related protein: cripto-1

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

somatic stem cell population maintenance

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

TAS

positive regulation of cell migration

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

A Nodal- and ALK4-independent signaling pathway activated by Cripto-1 through Glypican-1 and c-Src

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

cellular response to hepatocyte growth factor stimulus

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

cellular response to tumor necrosis factor

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

negative regulation of apoptotic process

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

cellular response to fibroblast growth factor stimulus

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

morphogenesis of a branching structure

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

TAS

cell migration involved in sprouting angiogenesis

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IMP

mammary gland development

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Cripto: a tumor growth factor and more

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

TAS

positive regulation of endothelial cell migration

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

cellular response to epidermal growth factor stimulus

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

heart development

determination method or standard

IDA

1 reference

retrieved

31 January 2018

stated in

Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13385&geneProductId=UniProtKB:P13385

determination method or standard

IDA

regulation of signal transduction

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

A Nodal- and ALK4-independent signaling pathway activated by Cripto-1 through Glypican-1 and c-Src

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

peptidyl-serine phosphorylation

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

positive regulation of cell population proliferation

determination method or standard

IDA

TAS

2 references

retrieved

8 April 2019

stated in

Cripto: a tumor growth factor and more

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

TAS

retrieved

8 April 2019

stated in

Identification and biological characterization of an epidermal growth factor-related protein: cripto-1

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

positive regulation of peptidyl-tyrosine phosphorylation

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

cellular response to interferon-gamma

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

anterior/posterior axis specification, embryo

determination method or standard

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

ISS

regulation of signaling receptor activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IEA

embryo development ending in birth or egg hatching

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Cripto: a tumor growth factor and more

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

TAS

determination of left/right symmetry

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IBA

heart development

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1

GOA

curator

UniProt

UniProt protein ID

P13385

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IBA

anterior/posterior pattern specification

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IBA

BMP signaling pathway

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IBA

nodal signaling pathway

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IBA

anatomical structure development

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13385

determination method or standard

IBA

Gene Atlas image

PBB GE TDGF1 206286 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

EGF-like domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P13385

Cryptic/Cripto, CFC domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P13385

EGF-like, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P13385

Identifiers

RefSeq protein ID

NP_001167607

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6997

NP_003203

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6997

UniProt protein ID

P13385

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P13385

Ensembl protein ID

ENSP00000296145

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000296145

ENSP00000446375

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000446375

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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