Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse (Q77134006)

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3 December 2019

title

Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse (English)

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3 December 2019

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6

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3 December 2019

author name string

M B Genter

1

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3 December 2019

H C Liang

2

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3 December 2019

J Gu

3

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3 December 2019

X Ding

4

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3 December 2019

M Negishi

5

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3 December 2019

D W Nebert

7

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3 December 2019

language of work or name

English

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publication date

1 June 1998

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3 December 2019

published in

Biochemical Pharmacology

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3 December 2019

volume

55

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3 December 2019

issue

11

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3 December 2019

page(s)

1819-1826

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Paracetamol-induced acute renal failure in the absence of fulminant liver damage.

3 December 2019

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Renal necrosis, glutathione depletion, and covalent binding after acetaminophen

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Extrahepatic lesions induced by acetaminophen in the mouse

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Protection by dimethylsulfoxide against acetaminophen-induced hepatic, but not respiratory toxicity in the mouse

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Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen

7 January 2021

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Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics

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Identification of the mouse liver 44-kDa acetaminophen-binding protein as a subunit of glutamine synthetase

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S-adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models

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Prednisolone stimulates hepatic glutathione synthesis in mice. Protection by prednisolone against acetaminophen hepatotoxicity in vivo

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Clofibrate pretreatment diminishes acetaminophen's selective covalent binding and hepatotoxicity.

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Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4

7 January 2021

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The effect of propylene glycol on the P450-dependent metabolism of acetaminophen and other chemicals in subcellular fractions of mouse liver

7 January 2021

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Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity

7 January 2021

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Purification and characterization of two unique forms of cytochrome P-450 from rabbit nasal microsomes

7 January 2021

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Immunolocalization of cytochromes P-450olf1 and P-450olf2 in rat olfactory mucosa

7 January 2021

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cDNA cloning, heterologous expression, and characterization of mouse CYP2G1, an olfactory-specific steroid hydroxylase

7 January 2021

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Steroid metabolism by rabbit olfactory-specific P450 2G1

7 January 2021

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Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism

7 January 2021

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Histopathologic examination of the rat nasal cavity

7 January 2021

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Effects of P450 inhibition and induction on the olfactory toxicity of beta,beta'-iminodipropionitrile (IDPN) in the rat.

7 January 2021

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Molecular engineering of microsomal P450 2a-4 to a stable, water-soluble enzyme.

7 January 2021

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Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen

7 January 2021

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Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen.

7 January 2021

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Nasal diagrams: a tool for recording the distribution of nasal lesions in rats and mice.

7 January 2021

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Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity

7 January 2021

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Species differences in the hepatotoxicity of paracetamol are due to differences in the rate of conversion to its cytotoxic metabolite.

7 January 2021

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Role of CYP2E1 in the hepatotoxicity of acetaminophen

7 January 2021

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Modulation of rat hepatic microsomal monooxygenase enzymes and cytotoxicity by diallyl sulfide.

7 January 2021

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Initiation and post-initiation chemopreventive effects of diallyl sulfide in esophageal carcinogenesis

7 January 2021

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How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress

7 January 2021

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10.1016/S0006-2952(98)00004-5

7 January 2021

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9714300%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

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