Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites (Q77448624)

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5 December 2019

title

Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites (English)

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5 December 2019

author name string

S M Bailey

1

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5 December 2019

A D Lewis

2

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5 December 2019

R J Knox

3

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5 December 2019

L H Patterson

4

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5 December 2019

G R Fisher

5

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5 December 2019

P Workman

6

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5 December 2019

language of work or name

English

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publication date

1 September 1998

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5 December 2019

published in

Biochemical Pharmacology

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5 December 2019

volume

56

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5 December 2019

issue

5

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5 December 2019

page(s)

613-621

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EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models

5 December 2019

cites work

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Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug E09.

7 January 2021

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A randomized phase II study with two schedules of the novel indoloquinone EO9 in non-small-cell lung cancer: a study of the EORTC Early Clinical Studies Group (ECSG)

7 January 2021

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NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals

7 January 2021

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Free radical formation and DNA strand breakage during metabolism of diaziquone by NAD(P)H quinone-acceptor oxidoreductase (DT-diaphorase) and NADPH cytochrome c reductase.

7 January 2021

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The pH-dependent reduction of Adriamycin catalysed by NADH:cytochrome b5 reductase

7 January 2021

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DT-diaphorase and cancer chemotherapy

7 January 2021

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The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

7 January 2021

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Cytosolic NAD(P)H:(quinone-acceptor)oxidoreductase in human normal and tumor tissue: effects of cigarette smoking and alcohol

7 January 2021

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High levels of expression of the NAD(P)H:Quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin

7 January 2021

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The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

7 January 2021

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The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)

7 January 2021

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DT-diaphorase: questionable role in mitomycin C resistance, but a target for novel bioreductive drugs?

7 January 2021

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A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells

7 January 2021

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DT diaphorase. I. Purification from the soluble fraction of rat-liver cytoplasm, and properties

7 January 2021

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Problems associated with spin trapping oxygen-centered free radicals in biological systems

7 January 2021

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DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.

7 January 2021

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Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia

7 January 2021

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Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression

7 January 2021

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EO9: relationship between DT-diaphorase levels and response in vitro and in vivo

7 January 2021

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Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.

7 January 2021

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Hypoxia in tumors: a paradigm for the approach to biochemical and physiologic heterogeneity

7 January 2021

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Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.

7 January 2021

1 reference

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Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines

7 January 2021

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Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase

7 January 2021

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Generation of a free radical from calphostin C by microsomal cytochrome P450 reductase in rat and human liver

7 January 2021

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The autoxidation of the reduced forms of EO9

7 January 2021

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Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones

7 January 2021

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The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.

7 January 2021

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-2952(97)00661-8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9783730%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

1 reference