Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity (Q77508889)

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scientific article published on 01 November 1998

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English	Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity	scientific article published on 01 November 1998

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scholarly article

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6 December 2019

Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity (English)

1 reference

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6 December 2019

author name string

L Stefanis

1

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6 December 2019

C M Troy

2

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6 December 2019

H Qi

3

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6 December 2019

M L Shelanski

4

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6 December 2019

L A Greene

5

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6 December 2019

publication date

1 November 1998

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6 December 2019

Journal of Neuroscience

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6 December 2019

18

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6 December 2019

22

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6 December 2019

9204-9215

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6 December 2019

Purification and characterization of active human interleukin-1 beta-converting enzyme from THP.1 monocytic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defects in regulation of apoptosis in caspase-2-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and expression of the cDNA encoding rat caspase-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression, refolding, and autocatalytic proteolytic processing of the interleukin-1 beta-converting enzyme precursor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 affects survival but not neuronal differentiation of PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of caspase-2 in apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificities of caspase family proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of trypsin-like serine proteases inhibit processing of the caspase Nedd-2 and protect PC12 cells and sympathetic neurons from death evoked by withdrawal of trophic support

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A license to kill

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for CPP32 activation in the absence of apoptosis during T lymphocyte stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimerization and autoprocessing of the Nedd2 (caspase-2) precursor requires both the prodomain and the carboxyl-terminal regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Commitment and effector phases of the physiological cell death pathway elucidated with respect to Bcl-2 caspase, and cyclin-dependent kinase activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional activation of Nedd2/ICH-1 (caspase-2) is an early process in apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Need for caspase-2 in apoptosis of growth-factor-deprived PC12 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissecting processing and apoptotic activity of a cysteine protease by mutant analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9801360

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.18-22-09204.1998

1 reference

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6 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9801360%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9801360%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

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