5,5-trans lactone-containing inhibitors of serine proteases: identification of a novel, acylating thrombin inhibitor (Q77749611)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

title

5,5-trans lactone-containing inhibitors of serine proteases: identification of a novel, acylating thrombin inhibitor (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

author name string

Finch H

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Pegg NA

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

McLaren J

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Lowdon A

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Bolton R

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Coote SJ

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Dyer U

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Montana JG

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Owen MR

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Dowle M

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Buckley D

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Ross BC

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Campbell C

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Dix C

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Mooney C

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Man-Tang C

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

Patel C

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

publication date

1 November 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

Bioorganic & Medicinal Chemistry Letters

8 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

issue

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

page(s)

2955-2960

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profile

8 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

Orally Active .beta.-Lactam Inhibitors of Human Leukocyte Elastase. 3. Stereospecific Synthesis and Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

Rational design of boropeptide thrombin inhibitors: beta, beta-dialkyl-phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety profile

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

Discovery and development of the novel potent orally active thrombin inhibitor N-(9-hydroxy-9-fluorenecarboxy)prolyl trans-4-aminocyclohexylmethyl amide (L-372,460): coapplication of structure-based design and rapid multiple analogue synthesis on so

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

Dibasic benzo[b]thiophene derivatives as a novel class of active site-directed thrombin inhibitors. 1. Determination of the serine protease selectivity, structure-activity relationships, and binding orientation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

Tetracyclic triterpenoids from Melia azedarach, L.—III

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

Electrospray ionization mass spectrometry as a mechanistic tool: mass of human leucocyte elastase and a beta-lactam-derived E-I complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

Characterization of the interaction between human alpha-thrombin and methyl 3-(2-methyl-1-oxopropoxy)[1]benzothieno[3,2-b]furan-2-carboxylate (LY806303) using electrospray mass spectrometry and tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

Rapid validation of molecular structures of biological samples by electrospray-mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

Structure-activity relationship within a series of pyrazolidinone antibacterial agents. 1. Effect of nuclear modification on in vitro activity

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

Design of novel, potent, noncovalent inhibitors of thrombin with nonbasic P-1 substructures: rapid structure-activity studies by solid-phase synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-894X%2898%2900531-9

7 January 2021

10.1016/S0960-894X(98)00531-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9873654%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference