Mixed-backbone oligonucleotides as second-generation antisense agents with reduced phosphorothioate-related side effects (Q77749810)

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8 December 2019

title

Mixed-backbone oligonucleotides as second-generation antisense agents with reduced phosphorothioate-related side effects (English)

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8 December 2019

author name string

W Zhou

series ordinal

1

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8 December 2019

S Agrawal

series ordinal

2

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8 December 2019

publication date

1 November 1998

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Bioorganic & Medicinal Chemistry Letters

8 December 2019

published in

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8 December 2019

volume

8

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8 December 2019

issue

22

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8 December 2019

page(s)

3269-3274

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Antisense oligonucleotides: towards clinical trials

8 December 2019

cites work

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Detection of ribonuclease H-generated mRNA fragments in human leukemia cells following reversible membrane permeabilization in the presence of antisense oligodeoxynucleotides.

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7 January 2021

Hybrid oligonucleotides: synthesis, biophysical properties, stability studies, and biological activity

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Effect of different chemically modified oligodeoxynucleotides on immune stimulation

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Effects of synthetic oligonucleotides on human complement and coagulation

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7 January 2021

In vivo stability, disposition and metabolism of a "hybrid" oligonucleotide phosphorothioate in rats

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7 January 2021

A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth

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7 January 2021

Mixed backbone oligonucleotides: improvement in oligonucleotide-induced toxicity in vivo

1 reference

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7 January 2021

Effects of phosphorothioate oligodeoxyribonucleotide and oligoribonucleotides on human complement and coagulation

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7 January 2021

Pharmacokinetics and metabolism of an oligodeoxynucleotide phosphorothioate (GEM91) in cynomolgus monkeys following intravenous infusion

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7 January 2021

10.1016/S0960-894X(98)00591-5

Identifiers

DOI

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8 December 2019

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