Review: amino acid domains involved in constitutive activation of G-protein-coupled receptors (Q77790535)

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8 December 2019

review article

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title

Review: amino acid domains involved in constitutive activation of G-protein-coupled receptors (English)

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8 December 2019

author name string

P J Pauwels

series ordinal

1

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8 December 2019

T Wurch

series ordinal

2

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8 December 2019

publication date

1 January 1998

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8 December 2019

published in

Molecular Neurobiology

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8 December 2019

volume

17

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8 December 2019

issue

1-3

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8 December 2019

page(s)

109-135

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Histamine H2-receptor antagonists in peptic ulcer disease. Efficacy in healing peptic ulcers

8 December 2019

cites work

1 reference

12 December 2020

Sequence alignment of the G-protein coupled receptor superfamily

1 reference

12 December 2020

Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand

1 reference

12 December 2020

Detection of G protein-activator regions in M4 subtype muscarinic, cholinergic, and alpha 2-adrenergic receptors based upon characteristics in primary structure

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12 December 2020

Reverse intrinsic activity of antagonists on G protein-coupled receptors

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12 December 2020

Modulation of cardiac cyclic AMP metabolism by adenosine receptor agonists and antagonists

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12 December 2020

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation

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12 December 2020

Constitutively active mutants of rhodopsin

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12 December 2020

Receptor-effector coupling by G proteins: implications for normal and abnormal signal transduction

1 reference

12 December 2020

Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor

1 reference

12 December 2020

Agonist-independent inhibition of G protein activation by muscarinic acetylcholine receptor antagonists in cardiac membranes

1 reference

12 December 2020

Polymorphism in red photopigment underlies variation in colour matching

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12 December 2020

Two peptides from the alpha 2A-adrenergic receptor alter receptor G protein coupling by distinct mechanisms

1 reference

12 December 2020

Three-dimensional models of neurotransmitter G-binding protein-coupled receptors

1 reference

12 December 2020

Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation

1 reference

12 December 2020

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity

1 reference

12 December 2020

Autosomal dominant retinitis pigmentosa: Four new mutations in rhodopsin, one of them in the retinal attachment site

1 reference

12 December 2020

Prevention of Relapse of Reflux Esophagitis after Endoscopic Healing: The Efficacy and Safety of Omeprazole Compared with Ranitidine

1 reference

12 December 2020

Rhodopsin mutations in autosomal dominant retinitis pigmentosa

1 reference

12 December 2020

Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa

1 reference

12 December 2020

Tolerance to oral H2-receptor antagonists

1 reference

12 December 2020

Proline kinks in transmembrane alpha-helices

1 reference

12 December 2020

The absorption of bismuth and salicylate from oral doses of Pepto-Bismol (bismuth salicylate).

1 reference

12 December 2020

A point mutation of the rhodopsin gene in one form of retinitis pigmentosa

1 reference

12 December 2020

Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions

1 reference

12 December 2020

Chimeric muscarinic cholinergic: beta-adrenergic receptors that activate Gs in response to muscarinic agonists

1 reference

12 December 2020

Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function

1 reference

12 December 2020

Turning off the signal: desensitization of beta-adrenergic receptor function

1 reference

12 December 2020

Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa

1 reference

12 December 2020

Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization.

1 reference

12 December 2020

Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor

1 reference

12 December 2020

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins

1 reference

12 December 2020

The beta-adrenoceptor is precoupled to Gs in chicken erythrocyte membranes.

1 reference

12 December 2020

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

1 reference

12 December 2020

Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity

1 reference

12 December 2020

Mechanism of agonist and antagonist binding to alpha 2 adrenergic receptors: evidence for a precoupled receptor-guanine nucleotide protein complex.

1 reference

12 December 2020

The C-terminus of the S. cerevisiae alpha-pheromone receptor mediates an adaptive response to pheromone

1 reference

12 December 2020

The carboxy-terminal segment of the yeast alpha-factor receptor is a regulatory domain

1 reference

12 December 2020

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling

1 reference

12 December 2020

Structure-function analysis of the beta-adrenergic receptor

1 reference

12 December 2020

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity

1 reference

12 December 2020

Spontaneous coupling of the beta-adrenergic receptor to Ns in mammalian cardiac membranes.

1 reference

12 December 2020

Hypothesis about the function of membrane-buried proline residues in transport proteins

1 reference

12 December 2020

The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system

1 reference

12 December 2020

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor

1 reference

12 December 2020

Interaction of Convulsive Ligands with Benzodiazepine Receptors

1 reference

12 December 2020

Pharmacological proteus?

1 reference

12 December 2020

Endogenous ligands and inverse agonism

1 reference

12 December 2020

Agonist regulation of cellular Gs alpha-subunit levels in neuroblastoma x glioma hybrid NG108-15 cells transfected to express different levels of the human beta 2 adrenoceptor

1 reference

12 December 2020

High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype

1 reference

12 December 2020

A sporadic case of male-limited precocious puberty has the same constitutively activating point mutation in luteinizing hormone/choriogonadotropin receptor gene as familial cases

1 reference

12 December 2020

Detection and analysis of agonist-induced formation of the complex of the stimulatory guanine nucleotide-binding protein with adenylate cyclase in intact wild-type and beta 2-adrenoceptor-expressing NG108-15 cells

1 reference

12 December 2020

The two-state model of receptor activation

1 reference

12 December 2020

Constitutive activation of opsin: interaction of mutants with rhodopsin kinase and arrestin

1 reference

12 December 2020

1 reference

12 December 2020

Serotonergic antagonists differentially inhibit spontaneous activity and decrease ligand binding capacity of the rat 5-hydroxytryptamine type 2C receptor in Sf9 cells

1 reference

12 December 2020

A novel mutation of the luteinizing hormone receptor gene causing male gonadotropin-independent precocious puberty

1 reference

12 December 2020

Increased basal phosphorylation of the constitutively active serotonin 2C receptor accompanies agonist-mediated desensitization

1 reference

12 December 2020

Somatic and germline mutations of the TSH receptor gene in thyroid diseases

1 reference

12 December 2020

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

1 reference

12 December 2020

A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia

1 reference

12 December 2020

Activating and inactivating mutations in N- and C-terminal i3 loop junctions of muscarinic acetylcholine Hm1 receptors

1 reference

12 December 2020

A new constitutively activating point mutation in the luteinizing hormone/choriogonadotropin receptor gene in cases of male-limited precocious puberty

1 reference

12 December 2020

Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

1 reference

12 December 2020

Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty

1 reference

12 December 2020

The function of a highly-conserved arginine residue in activation of the muscarinic M1 receptor

1 reference

12 December 2020

Brief report: congenital hyperthyroidism caused by a mutation in the thyrotropin-receptor gene

1 reference

12 December 2020

Structure-function of muscarinic receptor coupling to G proteins. Random saturation mutagenesis identifies a critical determinant of receptor affinity for G proteins

1 reference

12 December 2020

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor

1 reference

12 December 2020

Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty.

1 reference

12 December 2020

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor

1 reference

12 December 2020

Inverse agonist activity of beta-adrenergic antagonists.

1 reference

12 December 2020

A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated

1 reference

12 December 2020

Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands

1 reference

12 December 2020

Antagonists of bradykinin that stabilize a G-protein-uncoupled state of the B2 receptor act as inverse agonists in rat myometrial cells.

1 reference

12 December 2020

Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy

1 reference

12 December 2020

Unoccupied beta-adrenoceptor-induced adenylyl cyclase stimulation in turkey erythrocyte membranes

1 reference

12 December 2020

Reciprocal binding properties of 5-hydroxytryptamine type 2C receptor agonists and inverse agonists

1 reference

12 December 2020

Regulation of basal adenylate cyclase activity in neuroblastoma x glioma hybrid, NG108-15, cells transfected to express the human beta 2 adrenoceptor: evidence for empty receptor stimulation of the adenylate cyclase cascade

1 reference

12 December 2020

Identification and functional characterization of two new somatic mutations causing constitutive activation of the thyrotropin receptor in hyperfunctioning autonomous adenomas of the thyroid

1 reference

12 December 2020

Precoupling of alpha-2B adrenergic receptors and G-proteins in transfected PC-12 cell membranes: influence of pertussis toxin and a lysine-directed cross-linker

1 reference

12 December 2020

Expanding horizons for receptors coupled to G proteins: diversity and disease

1 reference

12 December 2020

Novel mutations of thyrotropin receptor gene in thyroid hyperfunctioning adenomas. Rapid identification by fine needle aspiration biopsy

1 reference

12 December 2020

Constitutively active receptors as a disease-causing mechanism

1 reference

12 December 2020

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

1 reference

12 December 2020

Constitutive activation of opsin: influence of charge at position 134 and size at position 296.

1 reference

12 December 2020

Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness

1 reference

12 December 2020

Determinants of alpha 2-adrenergic receptor activation of G proteins: evidence for a precoupled receptor/G protein state

1 reference

12 December 2020

Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor

1 reference

12 December 2020

Mutations that alter the third cytoplasmic loop of the a-factor receptor lead to a constitutive and hypersensitive phenotype

1 reference

12 December 2020

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1 reference

12 December 2020

Activation of calcium currents in cardiac myocytes by empty beta-adrenoceptors

1 reference

12 December 2020

Do continuous infusions of omeprazole and ranitidine retain their effect with prolonged dosing?

1 reference

12 December 2020

Cosegregation of missense mutations of the luteinizing hormone receptor gene with familial male-limited precocious puberty

1 reference

12 December 2020

Agonist-independent effects of muscarinic antagonists on Ca2+ and K+ currents in frog and rat cardiac cells

1 reference

12 December 2020

Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindness

1 reference

12 December 2020

The probable arrangement of the helices in G protein-coupled receptors.

1 reference

12 December 2020

Constitutively active mutants of the alpha 2-adrenergic receptor

1 reference

12 December 2020

A deletion mutation in the third cytoplasmic loop of the mouse m1 muscarinic acetylcholine receptor unmasks cryptic G-protein binding sites.

1 reference

12 December 2020

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

1 reference

12 December 2020

Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function.

1 reference

12 December 2020

Pharmacology of a constitutively active muscarinic receptor generated by random mutagenesis

1 reference

12 December 2020

Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling

1 reference

12 December 2020

Constitutive activation of a single effector pathway: evidence for multiple activation states of a G protein-coupled receptor.

1 reference

12 December 2020

A constitutively active mutant thyrotropin-releasing hormone receptor is chronically down-regulated in pituitary cells: evidence using chlordiazepoxide as a negative antagonist

1 reference

12 December 2020

Mutations of two adjacent amino acids generate inactive and constitutively active forms of the human platelet-activating factor receptor

1 reference

12 December 2020

Chimeras of alpha1-adrenergic receptor subtypes identify critical residues that modulate active state isomerization

1 reference

12 December 2020

Differences in agonist-independent and -dependent 5-hydroxytryptamine2C receptor-mediated cell division

1 reference

12 December 2020

Constitutively active mutants of the alpha 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation

1 reference

12 December 2020

Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor.

1 reference

12 December 2020

Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors

1 reference

12 December 2020

Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop

1 reference

12 December 2020

Functional reconstitution in situ of 5-hydroxytryptamine2c (5HT2c) receptors with alphaq and inverse agonism of 5HT2c receptor antagonists

1 reference

12 December 2020

Heterogeneity of activating mutations of the human luteinizing hormone receptor in male-limited precocious puberty.

1 reference

12 December 2020

The C terminal tail of the histamine H2 receptor contains positive and negative signals important for signal transduction and receptor down-regulation.

1 reference

12 December 2020

Pharmacological characterisation of [35S]-GTPgammaS binding to Chinese hamster ovary cell membranes stably expressing cloned human 5-HT1D receptor subtypes

1 reference

12 December 2020

Silencing of the constitutive activity of the dopamine D1B receptor. Reciprocal mutations between D1 receptor subtypes delineate residues underlying activation properties

1 reference

12 December 2020

Mutagenesis of residues adjacent to transmembrane prolines alters D1 dopamine receptor binding and signal transduction

1 reference

12 December 2020

Inverse agonist-induced up-regulation of the human beta2-adrenoceptor in transfected neuroblastoma X glioma hybrid cells.

1 reference

12 December 2020

Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: role of G protein and adenylyl cyclase activation.

1 reference

12 December 2020

Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice

1 reference

12 December 2020

Mutation of Asn111 in the third transmembrane domain of the AT1A angiotensin II receptor induces its constitutive activation.

1 reference

12 December 2020

Synergism of constitutive activity in alpha 1-adrenergic receptor activation

1 reference

12 December 2020

Antipsychotics with inverse agonist activity at the dopamine D3 receptor

1 reference

12 December 2020

The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate

1 reference

12 December 2020

Characterisation of a cloned human 5-HT1A receptor cell line using [35S]GTP gamma S binding

1 reference

12 December 2020

Alanine exchanges of polar amino acids in the transmembrane domains of a platelet-activating factor receptor generate both constitutively active and inactive mutants

1 reference

12 December 2020

Structure/function relationships of calcitonin analogues as agonists, antagonists, or inverse agonists in a constitutively activated receptor cell system

1 reference

12 December 2020

Inhibition of the constitutive activity of human 5-HT1A receptors by the inverse agonist, spiperone but not the neutral antagonist, WAY 100,635

1 reference

12 December 2020

Agonist-independent tonic inhibitory influence of Gi on adenylate cyclase activity in rabbit ventricular myocardium and its removal by pertussis toxin: a role of empty receptor-mediated Gi activation

1 reference

12 December 2020

Constitutive activity of human prostaglandin E receptor EP3 isoforms

1 reference

12 December 2020

Pharmacology of muscarinic receptor subtypes constitutively activated by G proteins

1 reference

12 December 2020

The long cytoplasmic carboxyl terminus of the prostaglandin E2 receptor EP4 subtype is essential for agonist-induced desensitization

1 reference

12 December 2020

Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors

1 reference

12 December 2020

How efficacious are 5-HT1B/D receptor ligands: an answer from GTP gamma S binding studies with stably transfected C6-glial cell lines

1 reference

12 December 2020

Constitutive activation of the m5 muscarinic receptor by a series of mutations at the extracellular end of transmembrane 6.

1 reference

12 December 2020

5-HT 1B/D receptor antagonists

1 reference

12 December 2020

Stimulated [35S]GTP gamma S binding by 5-HT1A receptor agonists in recombinant cell lines. Modulation of apparent efficacy by G-protein activation state

1 reference

12 December 2020