Ala99ser mutation in RI alpha regulatory subunit of protein kinase A causes reduced kinase activation by cAMP and arrest of hormone-dependent breast cancer cell growth (Q77965413)

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scientific article published on 01 May 1999

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English	Ala99ser mutation in RI alpha regulatory subunit of protein kinase A causes reduced kinase activation by cAMP and arrest of hormone-dependent breast cancer cell growth	scientific article published on 01 May 1999

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10395071%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

Ala99ser mutation in RI alpha regulatory subunit of protein kinase A causes reduced kinase activation by cAMP and arrest of hormone-dependent breast cancer cell growth (English)

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Europe PubMed Central

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9 December 2019

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G R Lee

1

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9 December 2019

S N Kim

2

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9 December 2019

K Noguchi

3

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9 December 2019

S D Park

4

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9 December 2019

S H Hong

5

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9 December 2019

Y S Cho-Chung

6

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9 December 2019

publication date

1 May 1999

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9 December 2019

Molecular and Cellular Biochemistry

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9 December 2019

195

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9 December 2019

1-2

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9 December 2019

77-86

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9 December 2019

Point mutation of the autophosphorylation site or in the nuclear location signal causes protein kinase A RII beta regulatory subunit to lose its ability to revert transformed fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CAMP-dependent protein kinase: prototype for a family of enzymes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of the type II regulatory subunit of the cAMP-dependent protein kinase eliminates the type I holoenzyme in mouse cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation-Dephosphorylation of Enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the cAMP-dependent protein kinase system using molecular genetic approaches

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth arrest and induction of apoptosis in breast cancer cells by antisense depletion of protein kinase A-RI alpha subunit: p53-independent mechanism of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hormonal activation of gene transcription in ras-transformed NIH3T3 cells overexpressing RII alpha and RII beta subunits of the cAMP-dependent protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the cellular and subcellular concentrations and distribution of cyclic nucleotide-dependent protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The consequences of introducing an autophosphorylation site into the type I regulatory subunit of cAMP-dependent protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type II regulatory subunit of protein kinase restores cAMP-dependent transcription in a cAMP-unresponsive cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Types of cyclic AMP binding proteins in human breast cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3'-5'-cyclic adenosine monophosphate-dependent protein kinase from human testis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumour cyclic AMP binding proteins and endocrine responsiveness in patients with inoperable breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Infection with a TGF-alpha retroviral vector transforms normal mouse mammary epithelial cells but not normal rat fibroblasts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-cycle analysis using a monoclonal antibody to BrdUrd.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human testis cDNA for the regulatory subunit RII alpha of cAMP-dependent protein kinase encodes an alternate amino-terminal region

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered cellular ratio of type I and type II cyclic AMP-dependent protein kinase in human mammary tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The RI alpha subunit of protein kinase A controls serum dependency and entry into cell cycle of human mammary epithelial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10395071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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