Role of AKT1 in 17beta-estradiol- and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells (Q78054808)

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scientific article published on 01 August 1999

Language	Label	Description	Also known as
English	Role of AKT1 in 17beta-estradiol- and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells	scientific article published on 01 August 1999

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scholarly article

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10 December 2019

Role of AKT1 in 17beta-estradiol- and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells (English)

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10 December 2019

breast carcinoma

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inferred from title

apoptotic process

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author name string

S Ahmad

1

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10 December 2019

N Singh

2

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10 December 2019

R I Glazer

3

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1 August 1999

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10 December 2019

Biochemical Pharmacology

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58

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10 December 2019

3

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10 December 2019

425-430

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A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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Pleckstrin domain homology

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High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

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Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

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Akt signaling: linking membrane events to life and death decisions

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

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AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

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Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

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Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

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The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins

1 reference

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based on heuristic

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Modifications of vectors pEF-BOS, pcDNA1 and pcDNA3 result in improved convenience and expression

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7 January 2021

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Identifiers

10.1016/S0006-2952(99)00125-2

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Europe PubMed Central

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10 December 2019

1 reference

Europe PubMed Central

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10 December 2019

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